Document Detail

Angiotensin-converting enzyme inhibitor-related angioedema: how to deal with it.
MedLine Citation:
PMID:  16907654     Owner:  NLM     Status:  MEDLINE    
Angiotensin-converting enzyme inhibitor-related angioedema is a well documented condition, which seems to occur in up to 1% of treated patients. It represents a problem for both the clinician and the patient: for the clinician, the diagnosis may be difficult due to its peculiar clinical characteristics, whereas for the misdiagnosed patient the delay prolongs a potentially dangerous situation. If the drug is not discontinued, the attacks tend to become worse and even life-threatening. There are now evidences that increased levels of bradykinin have an important role in the pathophysiology of attacks and, moreover, there are genetic factors that render certain individuals susceptible to angiotensin-converting enzyme inhibitor-related angioedema. In this review, the authors analyse the pathogenetic mechanism, the clinical presentation, the management and future perspectives of research on this condition.
Laura Beltrami; Lorenza C Zingale; Stefano Carugo; Marco Cicardi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on drug safety     Volume:  5     ISSN:  1744-764X     ISO Abbreviation:  Expert Opin Drug Saf     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-15     Completed Date:  2006-08-23     Revised Date:  2008-04-14    
Medline Journal Info:
Nlm Unique ID:  101163027     Medline TA:  Expert Opin Drug Saf     Country:  England    
Other Details:
Languages:  eng     Pagination:  643-9     Citation Subset:  IM    
San Giuseppe Hospital-AFaR, University of Milan, Department of Internal Medicine, Via San Vittore 12, 20123, Milan, Italy.
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MeSH Terms
Angioedema / chemically induced*,  drug therapy,  physiopathology
Angiotensin-Converting Enzyme Inhibitors / adverse effects*
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Bradykinin / analogs & derivatives,  therapeutic use
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Anti-Inflammatory Agents, Non-Steroidal; 130308-48-4/icatibant; 58-82-2/Bradykinin
Comment In:
Expert Opin Drug Saf. 2006 Nov;5(6):739-40   [PMID:  17044798 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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