Document Detail

Angiotensin-converting enzyme inhibitor-induced cough.
MedLine Citation:
PMID:  2542908     Owner:  NLM     Status:  MEDLINE    
A 65-year-old woman started taking enalapril 2.5 mg daily for hypertension. Twelve days later she complained of a persistent, dry cough. Due to the coughing and a preexisting cystocele, she developed stress incontinence and a marked decline in her functional status. The coughing and incontinence resolved with the discontinuation of enalapril. During a subsequent hospitalization the patient received captopril 6.25 mg twice daily for congestive heart failure. Within 24 hours the dry cough recurred. It resolved with the discontinuation of the drug. Cough is a symptom that is generally not recognized as a drug side effect. However, increasing numbers of case reports document angiotensin-converting enzyme inhibitor-induced cough. Although the actual frequency and mechanism are currently unknown, the dry cough typically begins early in the course of therapy. It may be specific to this pharmacologic class rather than to one individual agent. Age and sex may be contributing factors. While cough has been considered a minor side effect, unnecessary hospitalizations and inappropriate treatments may easily result. Even minor adverse reactions may have an impact on a patient's quality of life.
A L Hume; J L Murphy; S E Lauerman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  9     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-29     Completed Date:  1989-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  88-90     Citation Subset:  IM    
Department of Pharmacy Practice, University of Rhode Island, Kingston 02881-0810.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / adverse effects*
Cough / chemically induced*
Enalapril / adverse effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril

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