| Angiotensin-converting enzyme inhibitor-induced cough. | |
| | |
MedLine Citation:
|
PMID: 2542908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 65-year-old woman started taking enalapril 2.5 mg daily for hypertension. Twelve days later she complained of a persistent, dry cough. Due to the coughing and a preexisting cystocele, she developed stress incontinence and a marked decline in her functional status. The coughing and incontinence resolved with the discontinuation of enalapril. During a subsequent hospitalization the patient received captopril 6.25 mg twice daily for congestive heart failure. Within 24 hours the dry cough recurred. It resolved with the discontinuation of the drug. Cough is a symptom that is generally not recognized as a drug side effect. However, increasing numbers of case reports document angiotensin-converting enzyme inhibitor-induced cough. Although the actual frequency and mechanism are currently unknown, the dry cough typically begins early in the course of therapy. It may be specific to this pharmacologic class rather than to one individual agent. Age and sex may be contributing factors. While cough has been considered a minor side effect, unnecessary hospitalizations and inappropriate treatments may easily result. Even minor adverse reactions may have an impact on a patient's quality of life. |
| | |
Authors:
|
A L Hume; J L Murphy; S E Lauerman |
Related Documents
:
|
367088 - Long-term clinical experience with atenolol--a new selective beta-1-blocker with few si... 2446058 - Antihypertensive efficacy of ketanserin alone or in combination with a beta-blocker or ... 8896668 - Suggested guidelines for determining the trough-to-peak ratio of antihypertensive drugs. 23588518 - The quality of life of patients with lupus erythematosus influences cardiovascular capa... 11206598 - Patient compliance to a new enteric-coated weekly formulation of fluoxetine during cont... 8468108 - Iron protein succinylate in the treatment of iron deficiency: controlled, double-blind,... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Pharmacotherapy Volume: 9 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 1989 |
Date Detail:
|
Created Date: 1989-06-29 Completed Date: 1989-06-29 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 88-90 Citation Subset: IM |
Affiliation:
|
Department of Pharmacy Practice, University of Rhode Island, Kingston 02881-0810. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Angiotensin-Converting Enzyme Inhibitors / adverse effects* Cough / chemically induced* Enalapril / adverse effects* Female Humans |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysis.
Next Document: Cytophotometric analysis on nuclear DNA contents of human scirrhous gastric carcinoma.