Document Detail

Angiotensin converting enzyme inhibition and vascular hypertrophy in hypertension.
MedLine Citation:
PMID:  2285616     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of hypertension is associated with a remodeling of vascular structure. Follow has postulated that the decreased luminal area and thickened medial layer in hypertensive vessels enhances the vasoconstrictive response to vasoactive agents. It is hypothesized that this increase in vascular reactivity may serve to perpetuate hypertension. A growing body of evidence suggests that autocrine-paracrine vasoactive substances and growth factors modulate vascular structure in hypertension. We speculate that therapeutic interventions that normalize blood pressure as well as reverse the vascular remodeling process may have special clinical value. The role of the paracrine renin-angiotensin system and angiotensin converting enzyme inhibitors in hypertension is discussed in this context.
G H Gibbons; V J Dzau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  4     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1991-03-22     Completed Date:  1991-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
Molecular and Cellular Vascular Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Arteries / pathology
Blood Vessels / drug effects,  pathology*
Hormones / physiology
Hypertension / drug therapy*
Hypertrophy / drug therapy
Muscle, Smooth, Vascular / pathology
Grant Support
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Hormones

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