Document Detail

Angiotensin-converting enzyme inhibition, catecholamines and hemodynamics in essential hypertension.
MedLine Citation:
PMID:  6280474     Owner:  NLM     Status:  MEDLINE    
Captopril was given to 15 unselected patients with essential hypertension (WHO II) at a dose range of 300 to 600 mg/day. Hemodynamic indexes (thermodilution) as well as levels of plasma norepinephrine, epinephrine, renin activity and aldosterone were determined simultaneously at the end of 2 weeks of placebo and after 8 weeks of captopril treatment. Systolic and diastolic arterial pressures were reduced significantly by treatment both supine (p less than 0.0025) and standing (p less than 0.0025). The diastolic arterial pressure was normalized (less than 95 mm Hg) in five patients and significantly reduced in four, whereas six patients were considered poor responders (mean arterial pressure decrease 10 mm Hg or less). The decrease in arterial pressure correlated significantly with the reduction in total peripheral resistance (r = 0.71), whereas cardiac index did not change and stroke index increased because of a slight decrease of heart rate. Plasma and urinary norepinephrine and epinephrine did not change during treatment. Moreover, the response of both heart rate and plasma catecholamines to upright posture was not altered by captopril treatment. Plasma renin activity increased and plasma aldosterone concentration decreased during treatment. These results suggest that inhibition of converting enzyme activity by captopril induces a reduction in arterial pressure through a reduction in total peripheral resistance. There was no evidence of an appreciable reduction in sympathetic nervous system activity during therapy.
G Muiesan; C L Alicandri; E Agabiti-Rosei; R Fariello; M Beschi; E Boni; M Castellano; E Moniti; L Muiesan; G Romanelli; A Zanielli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  49     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1420-4     Citation Subset:  AIM; IM    
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MeSH Terms
Aldosterone / blood
Angiotensin-Converting Enzyme Inhibitors*
Blood Pressure / drug effects
Captopril / therapeutic use*
Epinephrine / blood*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / blood,  drug therapy*
Middle Aged
Norepinephrine / blood*
Proline / analogs & derivatives*
Renin / blood
Renin-Angiotensin System / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 147-85-3/Proline; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 52-39-1/Aldosterone; 62571-86-2/Captopril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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