| Angiotensin converting enzyme inhibition, AT1 receptor inhibition, and combination therapy with pacing induced heart failure: effects on left ventricular performance and regional blood flow patterns. | |
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MedLine Citation:
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PMID: 9747431 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: AT1 receptor activation has been demonstrated to cause increased vascular resistance properties which may be of particular importance in the setting of congestive heart failure (CHF). The overall goal of this study was to examine the effects of ACE inhibition (ACEI) alone, AT1 receptor blockade alone and combined ACEI and AT1 receptor blockade on LV pump function, systemic hemodynamics and regional blood flow patterns in the normal state and with the development of pacing induced CHF, both at rest and with treadmill induced exercise. METHODS AND RESULTS: Pigs (25 kg) were instrumented in order to measure cardiac output (CO), systemic (SVR) and pulmonary vascular (PVR) resistance, neurohormonal system activity, and myocardial blood flow distribution in the conscious state and assigned to one of 4 groups: (1) rapid atrial pacing (240 bpm) for 3 weeks (n = 7); (2) ACEI (benazeprilat, 3.75 mg/day) and pacing (n = 7); (3) AT1 receptor blockade (valsartan, 60 mg/day) and rapid pacing (n = 7); and (4) ACEI and AT1 receptor blockade (benazeprilat/valsartan, 1/60 mg/day, respectively) and pacing (n = 7). Measurements were obtained at rest and with treadmill exercise (15 degrees, 3 miles/h; 10 min) in the normal control state and after the completion of the treatment protocols. With rapid pacing, CO was reduced at rest and with exercise compared to controls. ACEI or AT1 blockade normalized CO at rest, but remained lower than control values with exercise. Combination therapy normalized CO both at rest and with exercise. Resting SVR in the CHF group was higher than controls and SVR fell to a similar degree with exercise; all treatment groups reduced resting SVR. With exercise, SVR was reduced from rapid pacing values in the ACEI and combination therapy groups. PVR increased by over 4-fold in the rapid pacing group both at rest and with exercise, and was reduced in all treatment groups. In the combination therapy group, PVR was similar to control values with exercise. Plasma catecholamines and endothelin levels were increased by over 3-fold with chronic rapid pacing, and were reduced in all treatment groups. In the combination therapy group, the relative increase in catecholamines and endothelin with exercise were significantly blunted when compared to rapid pacing only values. LV myocardial blood flow at rest was reduced in the rapid pacing only and monotherapy groups, but was normalized with combination therapy. CONCLUSION: These findings suggest that with developing CHF, combined ACE inhibition and AT1 receptor blockade improved vascular resistive properties and regional blood flow distribution to a greater degree than that of either treatment alone. Thus, combined ACEI and AT1 receptor blockade may provide unique benefits in the setting of CHF. |
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Authors:
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R S Krombach; M J Clair; J W Hendrick; W V Houck; J L Zellner; S B Kribbs; S Whitebread; R Mukherjee; M de Gasparo; F G Spinale |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cardiovascular research Volume: 38 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-10-15 Completed Date: 1998-10-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 631-45 Citation Subset: IM |
Affiliation:
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Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin I* Angiotensin-Converting Enzyme Inhibitors / pharmacology* Animals Benzazepines / pharmacology* Cardiac Pacing, Artificial Endothelins / blood Epinephrine / blood Heart Failure / blood, physiopathology* Hemodynamics / drug effects Male Norepinephrine / blood Physical Exertion Receptors, Angiotensin / antagonists & inhibitors* Regional Blood Flow / drug effects Renin / blood Swine Tetrazoles / pharmacology Valine / analogs & derivatives, pharmacology Ventricular Function, Left / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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HL-45024/HL/NHLBI NIH HHS; HL-56603/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Benzazepines; 0/Endothelins; 0/Receptors, Angiotensin; 0/Tetrazoles; 137862-53-4/valsartan; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7004-03-7/Valine; 89747-91-1/benazeprilat; 9041-90-1/Angiotensin I; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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