Document Detail


Angiotensin converting enzyme genotype influences the response to the angiotensin II receptor antagonist losartan in patients with hypertension.
MedLine Citation:
PMID:  15080371     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine whether the response to the angiotensin II receptor antagonist losartan varies depending on the angiotensin converting enzyme (ACE) genotype, we prospectively studied the effect of losartan in 42 hypertensive patients (20 men, 22 women; mean age: 60.4 years). After a 4-week observation period, losartan was administered at 50 mg/day and blood pressure was measured every 2 to 4 weeks for 12 weeks. Among the 42 patients, 19, 11, and 12, respectively, had the II, ID, and DD ACE genotypes. The baseline plasma ACE activity in patients with the ID or DD genotype was significantly higher than that in patients with the II genotype (13.8 +/- 4.2 vs. 9.6 +/- 2.3 IU/l; p = 0.0002). However, age, gender, baseline systolic and diastolic blood pressure (SBP/DBP), and body mass index (BMI) were not different among the groups. After 12 weeks of treatment with losartan alone, DBP in the ID+DD group was significantly higher than that in the II group (85.0 +/- 9.0 vs. 77.8 +/- 9.6 mmHg, p = 0.018), while the percent reduction in DBP in the ID+DD group was significantly smaller than that in the II group (7.9 +/- 8.8 vs. 14.3 +/- 10.1%, p = 0.035). Multiple regression analysis showed that the significant predictors of the DBP at 12 weeks were age (p = 0.030), ACE genotype (p = 0.029) and baseline DBP (p = 0.0001). The ACE genotype may be a determinant of the response to losartan in hypertensive patients.
Authors:
Yasuyuki Nakamura; Shinji Tamaki; Yasukazu Uchida; Nobuyuki Ohmichi; Osamu Yamaoka; Nobuo Miyauchi; Takehisa Fukuhara; Harumi Sayama; Tetsuhiro Yamada; Shinro Matsuo; Yutaka Yamada
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  27     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-14     Completed Date:  2004-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  137-40     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, Shiga University of Medical Science, Setatsukinowa-cho, Otsu 520-2192, Japan. nakamura@belle.shiga-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects,  genetics
Diastole
Female
Genotype
Humans
Hypertension / drug therapy*,  genetics*,  physiopathology
Losartan / therapeutic use*
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Prospective Studies
Receptors, Angiotensin / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Receptors, Angiotensin; 114798-26-4/Losartan; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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