Document Detail


Angiotensin-converting enzyme gene polymorphisms and the risk of psoriasis: a meta-analysis.
MedLine Citation:
PMID:  23621089     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: The gene coding for angiotensin-converting enzyme (ACE) has been reported to be associated with the development of psoriasis.
AIM: To evaluate the association of psoriasis risk and ACE polymorphisms.
METHODS: We carried out a retrieval of studies that explored associations between ACE polymorphism and psoriasis, and analysed the genotype frequencies.
RESULTS: In total, 8 studies with 1242 patients and 1646 controls were included. The genotype frequencies in all studies were in Hardy-Weinberg equilibrium. After pooling all studies, the results indicated that the I/I genotype was associated with risk of psoriasis (OR = 1.41, 95% CI 1.11-1.80, P = 0.005), whereas the I/D genotype may decrease the risk of psoriasis (OR = 0.71, 95% CI 0.56-0.90, P = 0.005) in Asian, but not in white populations.
CONCLUSIONS: Our study suggests that ACE polymorphism are associated with the risk of psoriasis in Asians, especially the I/I genotype and I allele. Further studies are needed to confirm our results.
Authors:
T Liu; Y Han; L Lu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  38     ISSN:  1365-2230     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  352-9     Citation Subset:  IM    
Copyright Information:
© The Author(s) CED © 2013 British Association of Dermatologists.
Affiliation:
Department of Physiology, Kunming Medical University, Kunming, Yunnan, China.
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