Document Detail


Angiotensin-converting enzyme gene polymorphism adds risk for the severity of coronary atherosclerosis in smokers.
MedLine Citation:
PMID:  9322984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the relation between the angiotensin-converting enzyme (ACE) gene polymorphism and acute coronary syndromes with respect to environmental factors, we analyzed the association of genotype with the coronary angiographic findings of patients with acute myocardial infarction or unstable angina pectoris, and we examined the linkage of each genotype with established risk factors for coronary artery disease. We determined the ACE genotype in 152 Japanese patients with acute coronary syndromes and 399 healthy individuals. The genotype distributions were not different between the two groups (P=.74, chi2 test). In the former group, coronary angiograms were evaluated by criteria based on the number of diseased vessels, the number of stenotic lesions (> or = 50%), and the relative abnormal arterial portion (extent index). Although the number of stenotic lesions was higher in patients with the DD genotype than in those with the ID or II genotype (P=.006), there were no differences in the number of diseased vessels or the extent index. When only smokers were analyzed, the number of diseased vessels (P=.032), number of stenotic lesions (P=.003), and extent index (P=.019) were all higher in patients with the DD genotype than in those with the ID or II genotype. In contrast, these differences in the respective parameters did not exist in nonsmokers. The results indicate smoking-associated effects of the ACE genotype on the severity of coronary atherosclerosis.
Authors:
K Hibi; T Ishigami; K Kimura; M Nakao; T Iwamoto; K Tamura; T Nemoto; T Shimizu; Y Mochida; H Ochiai; S Umemura; M Ishii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  30     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-16     Completed Date:  1997-10-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-9     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Coronary Artery Disease / etiology*,  genetics
Female
Genotype
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic
Risk Factors
Smoking / adverse effects*
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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