| Angiotensin-converting enzyme gene polymorphism and respiratory muscle function in infants. | |
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MedLine Citation:
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PMID: 20812241 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Angiotensin-converting enzyme (ACE) gene contains a polymorphism consisting of either the presence (I) or absence (D) of a 287-bp fragment. Recent studies have suggested that the I-allele may be associated with superior exercise endurance; respiratory muscle function may be similarly influenced. The pressure-time index of inspiratory muscles (PTImus) is a measure of the load-capacity ratio of the inspiratory muscles. The objective of this study was to determine whether infants homozygous for the I-allele have lower PTImus compared to infants homozygous for the D-allele or heterozygous I/D. PATIENTS AND METHODS: One hundred thirty-two infants were studied. ACE genotyping was performed by polymerase chain reaction amplification, using DNA from peripheral blood. PTImus was calculated as (Pi(mean)/Pi(max)) × (T(i)/T(tot)), where Pi(mean) was the mean inspiratory pressure estimated from airway pressure, generated 100 ms after an occlusion (P(0.1)), Pi(max) was the maximum inspiratory pressure and T(i)/T(tot) was the ratio of the inspiratory time to the total respiratory cycle time. Pi(max) was the largest pressure generated during brief airway occlusions performed at the end of a spontaneous crying effort. RESULTS: Infants with I/I genotype had significantly lower PTImus than infants with either D/D or I/D genotypes (P = 0.000007). ACE genotype was significantly related (P = 0.005) to PTImus measurements, independent of other factors that may affect respiratory muscle function. CONCLUSION: These results suggest that an association of ACE genotypes with PTImus measurements may exist in infants. |
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Authors:
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Gabriel Dimitriou; Despina Papakonstantinou; Eleana F Stavrou; Sotirios Tzifas; Aggeliki Vervenioti; Aglaia Athanassiadou; Stefanos Mantagos |
Publication Detail:
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Type: Journal Article Date: 2010-09-01 |
Journal Detail:
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Title: Pediatric pulmonology Volume: 45 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 1233-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Neonatal Intensive Care Unit, Department of Pediatrics, University of Patras Medical School, Rio, Patras, Greece. gdimitriou@med.upatras.gr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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