Document Detail

Angiotensin-converting enzyme gene polymorphism in preeclampsia and normal pregnancy.
MedLine Citation:
PMID:  15467548     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to evaluate the angiotensin-converting enzyme gene polymorphism in pregnant women with and without preeclampsia. STUDY DESIGN: Preeclampsia was defined as hypertension and pathologic proteinuria in pregnant women after gestational week 20. Genomic DNA was isolated from leukocytes. The insertion-deletion polymorphism in intron 16 of the angiotensin-converting enzyme gene was detected in DNA samples with the use of the polymerase chain reaction. Chi-squared and Student t tests were used for statistical analysis. RESULTS: In preeclampsia (n=51 women) angiotensin-converting enzyme genotypes were deletion-D (DD) in 16 women (31%), insertion-I (II) in 12 women (24%), and insertion-deletion in 23 women (45%); in the control group (n=71), the angiotensin-converting enzyme genotypes were DD in 21 women (30%), II in 17 women (24%), and insertion-deletion in 33 women (46%). Angiotensin-converting enzyme genotype distribution and allelic frequencies were not different between groups. CONCLUSION: No difference in the angiotensin-converting enzyme genotype distribution was found between preeclampsia and normal pregnancy. The results showed no association between angiotensin-converting enzyme polymorphism and the development of preeclampsia.
Adriani O Galão; Lívia H de Souza; Bartira E Pinheiro da Costa; Rosane M Scheibe; Carlos E Poli de Figueiredo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  821-4     Citation Subset:  AIM; IM    
Programa de Pós-graduação em Clnica Médica e Ciências da Saúde (Nefrologia), Instituto de Pesquisas Biomédicas/Faculdade de Medicina/Hospital São Lucas, Pontifcia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
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MeSH Terms
Gene Deletion
Gene Frequency
Gestational Age
Mutagenesis, Insertional
Peptidyl-Dipeptidase A / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic / genetics*
Pre-Eclampsia / enzymology,  genetics*
Reg. No./Substance:

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