Document Detail


Angiotensin I-converting enzyme (ACE) inhibitors and restenosis after coronary artery stenting in patients with the DD genotype of the ACE gene.
MedLine Citation:
PMID:  12798565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We tested the hypothesis that patients with the DD genotype of the angiotensin I-converting enzyme (ACE) gene who are treated with ACE inhibitors are at a higher risk of restenosis after coronary stent placement than patients who do not receive ACE inhibitors. BACKGROUND: Two recent studies with a limited series of patients carrying the DD genotype suggested an unfavorable impact of the use of ACE inhibitors on the restenotic process after implantation of stents in coronary arteries. Because these findings may question the use of ACE inhibitors after coronary stenting, we examined this important issue in a large series of patients. METHODS: We determined the ACE gene I/D genotype of 2,222 consecutive patients with symptomatic coronary artery disease who underwent stent implantation. The patients with the DD genotype (n = 612) constituted the study population. The primary end point was in-stent restenosis, which was assessed as angiographic restenosis (> or =50% diameter stenosis at six-month follow-up) and clinical restenosis (need for target vessel revascularization due to symptoms or signs of ischemia in the presence of angiographic restenosis over one year after the intervention). RESULTS: Of the 612 patients with the DD genotype, 403 (65.8%) were treated with ACE inhibitors and 209 (34.2%) did not receive ACE inhibitors. The angiographic and clinical restenosis rates were not significantly different between the group treated with ACE inhibitors and the group not receiving ACE inhibitors (p = 0.55). Continuous measures of restenosis, minimal lumen diameter, diameter stenosis, late lumen loss, and loss index were also similar in both groups (p > or = 0.55). In addition, one-year survival free of myocardial infarction was not significantly different between the two groups (p = 0.27). CONCLUSIONS: In contrast to previous reports, our study provides evidence that patients carrying the DD genotype are not exposed to an increased risk of restenosis after stent placement when treated with ACE inhibitors.
Authors:
Werner Koch; Julinda Mehilli; Nicolas von Beckerath; Corinna Böttiger; Albert Schömig; Adnan Kastrati
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  41     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-11     Completed Date:  2003-07-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1957-61     Citation Subset:  AIM; IM    
Affiliation:
Deutsches Herzzentrum München, Experimentelle Kardiologie, Technische Universität München, Lazarettstrasse 36, D-80636 Munich, Germany. wkoch@dhm.mhn.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Vessel Prosthesis Implantation
Coronary Angiography
Coronary Artery Disease / enzymology*,  genetics,  therapy*
Coronary Restenosis / enzymology*,  genetics,  therapy*
Disease-Free Survival
Endpoint Determination
Female
Follow-Up Studies
Genetic Markers / drug effects,  genetics
Genotype
Humans
Incidence
Male
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Stents*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Genetic Markers; EC 3.4.15.1/Peptidyl-Dipeptidase A
Comments/Corrections
Comment In:
J Am Coll Cardiol. 2003 Jun 4;41(11):1962-3   [PMID:  12798566 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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