| Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function. | |
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MedLine Citation:
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PMID: 12881153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate to what extent and by what methods clinicians assess left ventricular (LV) function after an acute myocardial infarction (AMI) and how the results of the assessments relate to the use of angiotensin-converting enzyme (ACE) inhibitors; furthermore, to explore which main indications caused the clinicians to initiate ACE inhibitor therapy. DESIGN: From 16 hospitals we drew a sample of patients who were discharged with the diagnosis of AMI during a 3-month period in 1999/2000. Physicians in each hospital obtained the observed rate of use of cardiovascular drugs at discharge and also information on ejection fraction (EF) measurements. The results of the EF recordings were classified into three categories: >0.50, 0.40-0.50 and <0.40. The clinicians' main indications for drug use were reported. RESULTS: Among 767 patients discharged alive, EF was measured in 409 (53%), by echocardiography in 53% and by radionuclide ventriculography in 47%. Of the 409 patients 227 (55%) had EF >0.50, 95 (24%) EF 0.40-0.50 and 87 (21%) EF <0.40. Adjusted odds ratio for ACE inhibitor therapy being initiated during the AMI was 13.5 for those with EF <0.40 compared with those with EF >0.50. The main indication for starting ACE inhibitor therapy was heart failure (50%) followed by secondary prevention (42%). CONCLUSION: Measuring EF appears to be an important tool in the evaluation of AMI patients prior to discharge from hospital. Initiation of ACE inhibitor therapy related strongly to the results of the assessments. |
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Authors:
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Aasmund Reikvam; Elena Kvan; Knud Landmark; Ivar Aursnes; |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Scandinavian cardiovascular journal : SCJ Volume: 37 ISSN: 1401-7431 ISO Abbreviation: Scand. Cardiovasc. J. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-25 Completed Date: 2003-12-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9708377 Medline TA: Scand Cardiovasc J Country: Norway |
Other Details:
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Languages: eng Pagination: 130-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacotherapeutics, Faculty of Medicine, University of Oslo, Norway. asmund.reikvam@labmed.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiotensin-Converting Enzyme Inhibitors / administration & dosage* Cohort Studies Confidence Intervals Dose-Response Relationship, Drug Drug Administration Schedule Emergency Treatment Female Heart Function Tests Hemodynamics / physiology Humans Logistic Models Male Middle Aged Myocardial Infarction / diagnosis*, drug therapy*, mortality Norway Probability Prognosis Sampling Studies Severity of Illness Index Stroke Volume / drug effects* Survival Rate Treatment Outcome Ventricular Dysfunction, Left / drug therapy, physiopathology Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
| Comments/Corrections | |
Comment In:
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Scand Cardiovasc J. 2003 Jun;37(3):122-3
[PMID:
12881150
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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