Document Detail


Angiotensin converting enzyme 2 in the kidney.
MedLine Citation:
PMID:  18307733     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Angiotensin converting enzyme 2 (ACE2) is an important homeostatic component of the renin angiotensin system (RAS). ACE2 both degrades the vasoconstrictor, angiotensin II and generates the potent vasodilator peptide, angiotensin 1-7. These actions counterbalance those of ACE. 2. ACE2 is highly expressed in the healthy kidney, particularly in the proximal tubules, where it colocalizes with ACE and angiotensin receptors. 3. Kidney disease and subtotal nephrectomy is associated with a reduction in renal ACE2 expression, possibly facilitating the damaging effects of angiotensin II in the failing kidney. Acquired or genetic ACE2 deficiency also appears to exacerbate renal damage and albuminuria in experimental models, supporting this hypothesis. 4. ACE2 also has an important role in blood pressure control. Many models of hypertension are associated with reduced ACE2 expression. Although ACE2 KO animals are normotensive, in states associated with activation of the RAS, ACE2 overexpression improves blood pressure control and reduces angiotensin responsiveness.
Authors:
A Koitka; M E Cooper; M C Thomas; C Tikellis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  35     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-02-29     Completed Date:  2008-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  420-5     Citation Subset:  IM    
Affiliation:
Division of Diabetic Complications, Baker Medical Research Institute, Melbourne, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus / metabolism
Humans
Kidney / enzymology*
Kidney Diseases / metabolism
Peptidyl-Dipeptidase A / metabolism*
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A; EC 3.4.17.-/angiotensin converting enzyme 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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