| Angiotensin-converting Enzyme Gene Polymorphisms, Blood Pressure and Pulse Pressure in Subjects with Essential Hypertension in a South Sulawesi Indonesian Population. | |
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MedLine Citation:
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PMID: 23314967 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: to investigate the potential association between the ACE gene polymorphism, essential hypertension and pulse pressure. Methods: the study included 99 non-hypertensive and 104 hypertensive subjects. Hypertension is defined as systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg. Pulse pressure refers to the differences between the systolic blood pressure and diastolic blood pressure. DNA amplication to examine ACE I/D polymorphism was conducted by Rigat-modification PCR method. Results: this study showed no significant difference in genotype distribution and allele frequency between two groups. We found PP >60 mmHg is different between ACE gene genotype. Genotype DD has a risk of 1.8 times of having PP >60 mmHg than ID genotype while DD genotype has a risk of 4.4 times of having PP >60mg than II genotype. Conclusion: this study does not support that the I/D polymorphism at ACE gene locus associated with hypertension in Makassar, South-Sulawesi, Indonesia. However, there were a significant correlation with pulse pressure independent from blood pressure. |
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Authors:
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Haerani Rasyid; Syakib Bakri; Irawan Yusuf |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Indonesiana Volume: 44 ISSN: 0125-9326 ISO Abbreviation: Acta Med Indones Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2013-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7901042 Medline TA: Acta Med Indones Country: Indonesia |
Other Details:
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Languages: eng Pagination: 280-3 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Faculty of Medicine, Hasanuddin University. Jl. Perintis Kemerdekaan Km.10 Makasar, 90245, Indonesia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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