Document Detail

Angiotensin-converting enzyme gene polymorphisms, blood pressure and pulse pressure in subjects with essential hypertension in a South Sulawesi Indonesian population.
MedLine Citation:
PMID:  23314967     Owner:  NLM     Status:  MEDLINE    
AIM: to investigate the potential association between the ACE gene polymorphism, essential hypertension and pulse pressure.
METHODS: the study included 99 non-hypertensive and 104 hypertensive subjects. Hypertension is defined as systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg. Pulse pressure refers to the differences between the systolic blood pressure and diastolic blood pressure. DNA amplication to examine ACE I/D polymorphism was conducted by Rigat-modification PCR method.
RESULTS: this study showed no significant difference in genotype distribution and allele frequency between two groups. We found PP >60 mmHg is different between ACE gene genotype. Genotype DD has a risk of 1.8 times of having PP >60 mmHg than ID genotype while DD genotype has a risk of 4.4 times of having PP >60mg than II genotype.
CONCLUSION: this study does not support that the I/D polymorphism at ACE gene locus associated with hypertension in Makassar, South-Sulawesi, Indonesia. However, there were a significant correlation with pulse pressure independent from blood pressure.
Haerani Rasyid; Syakib Bakri; Irawan Yusuf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Indonesiana     Volume:  44     ISSN:  0125-9326     ISO Abbreviation:  Acta Med Indones     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-05-24     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7901042     Medline TA:  Acta Med Indones     Country:  Indonesia    
Other Details:
Languages:  eng     Pagination:  280-3     Citation Subset:  IM    
Department of Nutrition, Faculty of Medicine, Hasanuddin University. Jl. Perintis Kemerdekaan Km.10 Makasar, 90245, Indonesia.
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MeSH Terms
Blood Pressure
Case-Control Studies
Gene Frequency
Hypertension / epidemiology,  genetics*
Indonesia / epidemiology
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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