| Angiotensin Type 1A Receptors in C1 Neurons of the Rostral Ventrolateral Medulla Modulate the Pressor Response to Aversive Stress. | |
| | |
MedLine Citation:
|
PMID: 22323719 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The rise in blood pressure during an acute aversive stress has been suggested to involve activation of angiotensin type 1A receptors (AT(1A)Rs) at various sites within the brain, including the rostral ventrolateral medulla. In this study we examine the involvement of AT(1A)Rs associated with a subclass of sympathetic premotor neurons of the rostral ventrolateral medulla, the C1 neurons. The distribution of putative AT(1A)R-expressing cells was mapped throughout the brains of three transgenic mice with a bacterial artificial chromosome-expressing green fluorescent protein under the control of the AT(1A)R promoter. The overall distribution correlated with that of the AT(1A)Rs mapped by other methods and demonstrated that the majority of C1 neurons express the AT(1A)R. Cre-recombinase expression in C1 neurons of AT(1A)R-floxed mice enabled demonstration that the pressor response to microinjection of angiotensin II into the rostral ventrolateral medulla is dependent upon expression of the AT(1A)R in these neurons. Lentiviral-induced expression of wild-type AT(1A)Rs in C1 neurons of global AT(1A)R knock-out mice, implanted with radiotelemeter devices for recording blood pressure, modulated the pressor response to aversive stress. During prolonged cage-switch stress, expression of AT(1A)Rs in C1 neurons induced a greater sustained pressor response when compared to the control viral-injected group (22 ± 4 mmHg for AT(1A)R vs 10 ± 1 mmHg for GFP; p < 0.001), which was restored toward that of the wild-type group (28 ± 2 mmHg). This study demonstrates that AT(1A)R expression by C1 neurons is essential for the pressor response to angiotensin II and that this pathway plays an important role in the pressor response to aversive stress. |
| | |
Authors:
|
Daian Chen; Nikola Jancovski; Jaspreet K Bassi; Thu-Phuc Nguyen-Huu; Yan-Ting Choong; Kesia Palma-Rigo; Pamela J Davern; Susan B Gurley; Walter G Thomas; Geoffrey A Head; Andrew M Allen |
Related Documents
:
|
12924469 - Three-dimensional reconstruction of a rhesus monkey brain from the friedrich sanides co... 8264969 - Changes in cortical field potentials during learning processes of go/no-go reaction tim... 22291349 - The neural substrates of sensorimotor gating of the startle reflex: a review of recent ... 22708629 - The morphology and variability of the caudal rami of the superior temporal sulcus. 22805069 - Spatiotemporal visualization of deep brain stimulation-induced effects in the subthalam... 17177259 - Species differences in the localization of soluble guanylyl cyclase subunits in monkey ... 18494259 - Self-organization and pattern formation in primate cortical networks. 762269 - Anomalous ipsilateral retinotectal projections in syrian hamsters with early lesions: t... 12586449 - Evidence for disturbed cortical signal processing and altered serotonergic neurotransmi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 32 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-02-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 2051-61 Citation Subset: IM |
Affiliation:
|
Department of Physiology and Florey Neurosciences Institutes, University of Melbourne, Melbourne, Victoria 3010, Australia, Neuropharmacology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia, Division of Nephrology, Department of Medicine, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, and School of Biomedical Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential Effects between ?-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid ...
Next Document: Plasticity of subventricular zone neuroprogenitors in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyri...