Document Detail

Angiotensin II type 2 receptor in chronic kidney disease: the good side of angiotensin II?
MedLine Citation:
PMID:  19404281     Owner:  NLM     Status:  MEDLINE    
Angiotensin II is believed to mediate blood pressure-independent progressive renal damage in chronic kidney disease (CKD). The evidence is less definitive than has been implied, and the studies by Benndorf et al. suggest that angiotensin II acting through its type 2 receptor may even have beneficial effects, although the responsible mechanisms remain to be defined. These and other data suggest that the concept of blood pressure-independent angiotensin signaling being uniformly deleterious in CKD is an oversimplification that needs re-evaluation.
Karen A Griffin; Anil K Bidani
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  75     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1006-8     Citation Subset:  IM    
Loyola University Medical Center and Hines Veterans Affairs Hospital, Department of Nephrology, Maywood, Illinois, USA. kgriffi
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MeSH Terms
Angiotensin II / physiology*
Blood Pressure
Kidney Failure, Chronic / metabolism*
Receptor, Angiotensin, Type 2 / deficiency,  physiology*
Signal Transduction
Reg. No./Substance:
0/Receptor, Angiotensin, Type 2; 11128-99-7/Angiotensin II

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