| Angiotensin II type 2 receptor in chronic kidney disease: the good side of angiotensin II? | |
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MedLine Citation:
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PMID: 19404281 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II is believed to mediate blood pressure-independent progressive renal damage in chronic kidney disease (CKD). The evidence is less definitive than has been implied, and the studies by Benndorf et al. suggest that angiotensin II acting through its type 2 receptor may even have beneficial effects, although the responsible mechanisms remain to be defined. These and other data suggest that the concept of blood pressure-independent angiotensin signaling being uniformly deleterious in CKD is an oversimplification that needs re-evaluation. |
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Authors:
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Karen A Griffin; Anil K Bidani |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kidney international Volume: 75 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-30 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 1006-8 Citation Subset: IM |
Affiliation:
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Loyola University Medical Center and Hines Veterans Affairs Hospital, Department of Nephrology, Maywood, Illinois, USA. kgriffi @lumc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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physiology* Animals Blood Pressure Humans Kidney Failure, Chronic / metabolism* Receptor, Angiotensin, Type 2 / deficiency, physiology* Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Angiotensin, Type 2; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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