| Angiotensin II type 1 receptor blocker attenuates diabetes-induced atrial structural remodeling. | |
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MedLine Citation:
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PMID: 21802905 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Diabetes mellitus promotes atrial structural remodeling, thereby producing atrial arrhythmogenicity, where advanced glycation endproducts (AGEs) and their receptor (RAGE) are implicated to play a role in the pathogenesis. PURPOSE: We investigated the effects of candesartan, an angiotensin type II receptor blocker, on the diabetes-induced atrial structural change. METHODS AND RESULTS: Diabetes was induced in 8-week-old female Sprague-Dawley rats by intraperitoneal injection of streptozotocin at 70mg/kg. Osmotic pumps were simultaneously set to infuse candesartan at a subdepressor dose of 0.05mg/kg/day. Twelve weeks after the induction of diabetes, the blood glucose and glycated hemoglobin A1c were significantly higher in streptozotocin-injected rats than those in control rats, and were not affected by candesartan treatment. The atria of diabetic rats showed remarkable diffuse interstitial fibrosis with more enhanced protein expressions of RAGE and connective tissue growth factor (CTGF) compared with control ones. The treatment with candesartan significantly reduced CTGF expression and effectively suppressed the development of fibrotic deposition in diabetic animals. CONCLUSIONS: Candesartan reduced CTGF expression and attenuated the fibrosis in diabetic rat atria. These results implied the protective effects of candesartan on diabetes-related atrial arrhythmias. |
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Authors:
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Takeshi Kato; Takeshi Yamashita; Akiko Sekiguchi; Takayuki Tsuneda; Kouichi Sagara; Masayuki Takamura; Shuichi Kaneko; Tadanori Aizawa; Long-Tai Fu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-28 |
Journal Detail:
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Title: Journal of cardiology Volume: - ISSN: 1876-4738 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-8-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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The Cardiovascular Institute, Tokyo, Japan; Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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