Document Detail

Angiotensin II type 1 receptor antagonists prevent glucose-induced increases in islet blood flow in rats.
MedLine Citation:
PMID:  18937099     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Renin-angiotensin system inhibitors are reported to be beneficial in delaying the onset of diabetes mellitus. Since islet blood hyperperfusion during hyperglycaemia may be detrimental to endothelium in pancreatic islets and eventually lead to beta-cell dysfunction, we studied acute and chronic effects of angiotensin II type 1 receptor blockers (ARB) on islet blood flow before and after glucose load. MATERIAL AND METHODS: Islet blood flow was measured using the colour microsphere method in anaesthetized Sprague-Dawley rats before and 3 min after glucose injection. RESULTS: Olmesartan significantly reduced blood pressure, but did not affect islet blood flow 10 min after its injection. However, pretreatment with olmesartan blunted the glucose-induced increase in islet blood flow (62% of control). In rats treated with olmesartan or candesartan for 4 weeks, islet blood flow was not different from untreated control, whereas the glucose-induced increase in islet blood flow was significantly suppressed in chronically ARB-treated rats (olmesartan 59% of control, candesartan 64% of control, respectively). Acute or chronic treatment with ARB did not change insulin secretion before and in response to glucose load. Pancreatic or duodenal blood flow was not affected by ARB treatment, although acute olmesartan administration reduced pancreatic blood flow after glucose load. CONCLUSION: ARB appears to suppress the hyperglycaemia-induced islet hyperperfusion, which may ameliorate haemodynamic stress in pancreatic islets.
Masanori Iwase; Yuji Uchizono; Sakae Nohara; Nobuhiro Sasaki; Kazuo Sonoki; Mitsuo Iida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  69     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Angiotensin II Type 1 Receptor Blockers / administration & dosage,  pharmacology*
Blood Glucose / drug effects
Blood Pressure / drug effects
Duodenum / blood supply,  drug effects
Glucose / administration & dosage,  pharmacology*
Imidazoles / pharmacology
Insulin / blood
Islets of Langerhans / blood supply*,  drug effects*
Rats, Sprague-Dawley
Regional Blood Flow / drug effects*
Tetrazoles / pharmacology
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Blood Glucose; 0/Imidazoles; 0/Tetrazoles; 0/olmesartan; 11061-68-0/Insulin; 50-99-7/Glucose

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