Document Detail


Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in San Luis.
MedLine Citation:
PMID:  17375465     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. The angiotensin II type 1 receptor mediates the vasoconstrictor and growth-promoting effects of Ang II. The A1166C polymorphism of the AT1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. We investigated the association between this A1166C polymorphism and hypertension in hypertense and normotense subjects from San Luis (Argentina) by mismatch PCR-RFLP analysis. Hypertense patients exhibited significant increases in lipid related values and body mass index. The frequency of occurrence of the C1166 allele was higher among patients with hypertension (0.19) than in the control group (0.06). No significant association was found between this polymorphism and essential hypertension in the study population, although the AC genotype prevalence was higher in patients with hypertension and positive family history of hypertension (32%) than in control subjects (12%). Patients with the A1166C polymorphism exhibited higher levels of serum total cholesterol, LDL-cholesterol and BMI than in control subjects. Taken together the genotype and biochemical parameters and considering the restrictive selection criteria used, the present results suggest a correlation between AT1 A1166C gene polymorphism and risk of cardiovascular disease.
Authors:
Alicia Viviana Lapierre; Maria Elena Arce; José Raul Lopez; Gladys María Ciuffo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biocell : official journal of the Sociedades Latinoamericanas de Microscopía Electronica ... et. al     Volume:  30     ISSN:  0327-9545     ISO Abbreviation:  Biocell     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438655     Medline TA:  Biocell     Country:  Argentina    
Other Details:
Languages:  eng     Pagination:  447-55     Citation Subset:  IM    
Affiliation:
Bioquímica Avanzada, Area de Biología Molecular, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina.
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MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions / genetics
Adult
Aged
Argentina
Female
Gene Frequency
Genotype
Humans
Hypertension / genetics*
Male
Middle Aged
Polymorphism, Single Nucleotide*
Receptor, Angiotensin, Type 1 / genetics*
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/Receptor, Angiotensin, Type 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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