| Angiotensin II reduces infarct size and has no effect on post-ischaemic contractile dysfunction in isolated rat hearts. | |
| | |
MedLine Citation:
|
PMID: 11522595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. In order to test the hypothesis that angiotensin II exacerbates myocardial ischaemia-reperfusion (IR) injury, we examined the effects of graded angiotension II concentrations of angiotensin II on IR injury in both working and non-working (Langendorff) isolated rat hearts. 2. Non-working hearts were subjected to 30 min aerobic perfusion (baseline) then 25 min of global, no-flow ischaemia followed by 30 min of reperfusion either in the absence (control, n=7) or presence of 1 (n=6) or 10 nM (n=5) angiotensin II). Recoveries of LV developed pressure and coronary flow after 30 min reperfusion in control hearts (58+/-9 and 40+/-8% of baseline levels, respectively) were no different from hearts treated with 1 or 10 nM angiotensin II. Infarct size (determined at the end of reperfusion by triphenyltetrazolium chloride staining) was reduced by angiotensin II in a concentration-dependent manner (from a control value of 27+/-3 to 18+/-4% and 9+/-3% of the LV, respectively). 3. Working hearts were subjected to 50 min pre-ischaemic (pre-I) aerobic perfusion then 30 min of global, no-flow ischaemia followed by 30 min of reperfusion either in the absence (control, n=14) or presence of 1 (n=8), 10 (n=7) or 100 nM (n=7) angiotensin II). In controls, post-ischaemic (post-I) left ventricular (LV) work and efficiency of oxygen consumption were depressed (43+/-9 and 42+/-10% of pre-I levels, respectively). The presence of angiotensin II throughout IR had no effect on LV work compared with control. 4. Thus, angiotensin II reduces infarct size in a concentration-dependent manner but has no effect on contractile stunning associated with IR in isolated rat hearts. |
| | |
Authors:
|
W R Ford; A S Clanachan; C R Hiley; B I Jugdutt |
Related Documents
:
|
8294705 - Adenosine triphosphate-sensitive potassium channel blocking agent ameliorates, but the ... 2988815 - The independent effects of oxygen radical scavengers on canine infarct size. reduction ... 19502555 - Reduction in myocardial infarct size at 48 hours after brief intravenous infusion of at... 17577105 - The pathway-selective estrogen receptor ligand way-169916 reduces infarct size after my... 7092775 - Effect of myocardial oxygen consumption on infarct size in experimental coronary artery... 18765075 - Acute stress cardiomyopathy. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of pharmacology Volume: 134 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2001 Sep |
Date Detail:
|
Created Date: 2001-08-27 Completed Date: 2001-10-11 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 38-45 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QJ, UK. wrf20@cam.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
pharmacology* Animals Blood Pressure / drug effects Coronary Circulation / drug effects Dose-Response Relationship, Drug Heart / drug effects*, physiopathology Heart Rate / drug effects Heart Ventricles / drug effects, physiopathology Male Myocardial Contraction / drug effects* Myocardial Infarction / pathology, physiopathology, prevention & control* Myocardial Ischemia / physiopathology* Perfusion Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
11128-99-7/Angiotensin II |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea...
Next Document: The mechanisms involved in the long-lasting neuroprotective effect of fluoxetine against MDMA ('ecst...