Document Detail

Angiotensin II receptor antagonist reduces subsequent uterine arterial dysfunction in pregnant offspring of protein-restricted rat dams.
MedLine Citation:
PMID:  22381101     Owner:  NLM     Status:  In-Data-Review    
Aim:  A low-protein diet (LPD) during pregnancy induces vascular dysfunction and hypertension in the offspring, prevented by administration of an angiotensin II type 1 (AT(1) ) receptor antagonist in early life to the offspring. Whether such protection extends to subsequent pregnancy is unknown; we therefore hypothesized that administration of a specific AT(1) receptor antagonist (losartan) in early life to offspring of LPD dams would improve vascular dysfunction in their uterine arteries when they, in turn, were pregnant. Methods:  Pregnant rats were randomly divided into two dietary groups fed a control (C) or protein-restricted (R) diet throughout pregnancy. Between two and 10 weeks postnatally, female offspring (F(1) ) were randomly assigned to drink either pure tap water (CO, RO) or water with losartan (CL, RL). Offspring were mated and killed on gestational day 19 or 20 in order to investigate uterine artery function. Results:  In pregnant offspring, vasoconstriction of the uterine arteries to phenylephrine (PE) and the thromboxane A2 mimetic U46619 was greater in RO than CO (F(1) ). Responses to both antagonists were suppressed in RL (F(1) ). Relaxation to sodium nitroprusside was increased in RO versus CO and suppressed in RL versus RO (F(1) ). Conclusion:  Administration of an AT(1) receptor antagonist to offspring during the suckling and juvenile period improves the uterine vascular dysfunction in pregnancy induced by prior maternal LPD during their development. Such treatment may contribute to decreasing the transmitted risks of maternal malnutrition from offspring to the subsequent generation.
Tomomi Saito; Yuka Musha; Miho Miyakawa; Shigeru Itoh; Mareki Ohtsuji; Mark A Hanson; Satoru Takeda
Publication Detail:
Type:  Journal Article     Date:  2012-02-16
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  38     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.
Departments of Obstetrics and Gynecology Pathology, School of Medicine, Juntendo University, Tokyo, Japan; Centre for Developmental Origins of Health and Disease, University of Southampton Institute of Developmental Sciences, Southampton General Hospital, Southampton, UK.
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