Document Detail

Angiotensin II: a peptidergic neurotransmitter in central autonomic pathways.
MedLine Citation:
PMID:  9481797     Owner:  NLM     Status:  MEDLINE    
Over the past 20 years a growing body of evidence has been directed to establishing the roles of angiotensin II (ANG) within the central nervous system. When this work began in the late 1970s the concept that this circulating hormone may also act as a neurotransmitter within the brain was contrary to the established dogma regarding synaptic transmission. There is now substantial anatomical data describing the distribution of ANG receptors, and the biochemical machinery for the production of this peptide, within the CNS. In addition many studies have described physiological and cellular consequences of activation of these receptors by both exogenous administration and endogenous release of ANG. Data from single cell studies are now also beginning to elucidate both signal transduction pathways and ion channels, influenced as a consequence of peptide actions at these receptors. These observations effectively establish the status of ANG as a chemical messenger (neurotransmitter) used for synaptic communication by specific populations of CNS neurons.
A V Ferguson; D L Washburn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Progress in neurobiology     Volume:  54     ISSN:  0301-0082     ISO Abbreviation:  Prog. Neurobiol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370121     Medline TA:  Prog Neurobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  169-92     Citation Subset:  IM    
Department of Physiology, Queen's University, Kingston, Ontario, Canada.
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MeSH Terms
Angiotensin II / physiology*
Autonomic Nervous System / chemistry*,  physiology*
Brain Chemistry / physiology*
Neuropeptides / physiology*
Reg. No./Substance:
0/Neuropeptides; 11128-99-7/Angiotensin II

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