Document Detail


Angiotensin II and oxidative stress in the failing heart.
MedLine Citation:
PMID:  22429089     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Significance: Despite recent medical advances, cardiovascular disease and heart failure continue to be major health concerns, and related mortality remains high. As a result, investigation of the mechanisms involved in the development of heart failure continues to be an active field of study. Recent Advances: The renin-angiotensin system and its effector molecule, angiotensin II, affect cardiac function through both systemic and local actions, and have been shown to play a major role in cardiac remodeling and dysfunction in the failing heart. Many of the downstream effects of angiotensin II signaling are mediated by elevated reactive oxygen species levels and oxidative stress, which have also been implicated in the pathology of heart failure. Critical Issues: Inhibitors of the renin-angiotensin system have proven beneficial in the treatment of patients at risk for and suffering from heart failure, but remain only partially effective. Reactive oxygen species can be generated from several different sources, and the oxidative state is normally tightly regulated in the heart. How angiotensin II increases reactive oxygen species levels and causes dysregulation of the cardiac oxidative state has been the subject of considerable interest in recent years. Future Directions: A better understanding of this process and the mechanisms involved should lead to the development of more effective heart failure therapies and improved outcomes.
Authors:
Daniela K Zablocki; Junichi Sadoshima
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  -     ISSN:  1557-7716     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
New Jersey Medical School, Cardiovascular Research Institute, Newark, New Jersey, United States; zablocdk@umdnj.edu.
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