| Angiotensin II induces endothelial cell senescence via the activation of mitogen-activated protein kinases. | |
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MedLine Citation:
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PMID: 18383564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vascular endothelial cells have a finite cell lifespan and eventually enter an irreversible growth arrest, cellular senescence. The functional changes associated with cellular senescence are thought to contribute to human aging and age-related cardiovascular disorders, for example, atherosclerosis. Angiotensin II (Ang II), a principal effector of the renin-angiotensin system (RAS), an important signaling molecule involved in atherogenic stimuli, is known to promote aging and cellular senescence. In the present study, induction of Ang II promoted a growth arrest with phenotypic characteristics of cell senescence, such as enlarged cell shapes, increased senescence-associated beta-galactosidase (SA-beta-gal) positive staining cells, and depressed cell proliferation. Ang II drastically decreased the expression level of Bcl-2, in part via the activation of extracellular signal-regulated kinase (ERK). Our results suggest that Ang II can induce HUVEC senescence; one of its molecular mechanisms is a probability that the mitogen-activated protein kinase (MAPK) signal pathway is involved in the process of pathological and physiological senescence of endothelial cells as well as vascular aging. |
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Authors:
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Haiyan Shan; XiaoJuan Bai; XiangMei Chen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell biochemistry and function Volume: 26 ISSN: 1099-0844 ISO Abbreviation: Cell Biochem. Funct. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-29 Completed Date: 2008-08-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8305874 Medline TA: Cell Biochem Funct Country: England |
Other Details:
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Languages: eng Pagination: 459-66 Citation Subset: IM |
Copyright Information:
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(c) 2008 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology* Cell Aging / drug effects* Cell Survival / drug effects Cells, Cultured Endothelial Cells / cytology, drug effects*, enzymology* Enzyme Activation / drug effects Gene Expression Regulation / drug effects Humans Microscopy, Electron, Transmission Mitogen-Activated Protein Kinases / metabolism* Proto-Oncogene Proteins c-bcl-2 / genetics, metabolism Umbilical Cord / drug effects, enzymology |
| Chemical | |
Reg. No./Substance:
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0/Proto-Oncogene Proteins c-bcl-2; 11128-99-7/Angiotensin II; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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