Document Detail


Angiotensin II induces endothelial cell senescence via the activation of mitogen-activated protein kinases.
MedLine Citation:
PMID:  18383564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular endothelial cells have a finite cell lifespan and eventually enter an irreversible growth arrest, cellular senescence. The functional changes associated with cellular senescence are thought to contribute to human aging and age-related cardiovascular disorders, for example, atherosclerosis. Angiotensin II (Ang II), a principal effector of the renin-angiotensin system (RAS), an important signaling molecule involved in atherogenic stimuli, is known to promote aging and cellular senescence. In the present study, induction of Ang II promoted a growth arrest with phenotypic characteristics of cell senescence, such as enlarged cell shapes, increased senescence-associated beta-galactosidase (SA-beta-gal) positive staining cells, and depressed cell proliferation. Ang II drastically decreased the expression level of Bcl-2, in part via the activation of extracellular signal-regulated kinase (ERK). Our results suggest that Ang II can induce HUVEC senescence; one of its molecular mechanisms is a probability that the mitogen-activated protein kinase (MAPK) signal pathway is involved in the process of pathological and physiological senescence of endothelial cells as well as vascular aging.
Authors:
Haiyan Shan; XiaoJuan Bai; XiangMei Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  26     ISSN:  1099-0844     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-29     Completed Date:  2008-08-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-66     Citation Subset:  IM    
Copyright Information:
(c) 2008 John Wiley & Sons, Ltd.
Affiliation:
Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology*
Cell Aging / drug effects*
Cell Survival / drug effects
Cells, Cultured
Endothelial Cells / cytology,  drug effects*,  enzymology*
Enzyme Activation / drug effects
Gene Expression Regulation / drug effects
Humans
Microscopy, Electron, Transmission
Mitogen-Activated Protein Kinases / metabolism*
Proto-Oncogene Proteins c-bcl-2 / genetics,  metabolism
Umbilical Cord / drug effects,  enzymology
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-bcl-2; 11128-99-7/Angiotensin II; EC 2.7.11.24/Mitogen-Activated Protein Kinases

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