| Angiotensin II increases host resistance to peritonitis. | |
| | |
MedLine Citation:
|
PMID: 10882664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Studies by other laboratories have shown that angiotensin II (AII) can affect the function of cells which comprise the immune system. In the present study, the effect of AII on the function of peritoneal macrophages and peripheral blood monocytes was assessed. In vitro exposure (4 h prior to assay) of peritoneal macrophages from mice and rats to AII increased the percentage of cells that phagocytosed opsonized yeast and the number of yeast per macrophage. Furthermore, AII increased the respiratory burst capacity of peritoneal macrophages from mice and rats and peripheral blood mononuclear cells from humans. Because of these observations, the effect of AII on host resistance to bacterial infection was assessed. Intraperitoneal administration of AII was shown to increase host resistance (reduced abscess formation) in an animal model of bacterial peritonitis. Studies were then conducted to assess whether parenteral administration of AII, a clinically relevant route, could affect peritoneal host resistance in a manner similar to that observed after peritoneal administration. These studies showed that subcutaneous administration of AII throughout the postinfection interval increased the level of host resistance to bacterial peritonitis. Furthermore, in a study which compared AII and Neupogen, an agent approved for use for the reduction of febrile neutropenia after myeloablative therapy, daily subcutaneous administration of AII reduced abscess size and incidence, whereas Neupogen did not have any therapeutic benefit in this model. These data suggest that AII may be of therapeutic benefit as an immunomodulatory agent. |
| | |
Authors:
|
K Rodgers; S Xiong; T Espinoza; N Roda; S Maldonado; G S diZerega |
Related Documents
:
|
2511844 - Abilities of activated macrophages to manifest tumoricidal activity and to generate rea... 9127564 - Adherence of mouse peritoneal macrophages following exposure to lead. 7002864 - Prevention of the immunosuppressive effects of glucocorticosteroids by cell-free factor... 1658174 - Absence of fmlp receptors on rat macrophages. 22204814 - Cd200 receptor and macrophage function in the intestine. 9056714 - Bcl-2 gene family in the nervous system. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Clinical and diagnostic laboratory immunology Volume: 7 ISSN: 1071-412X ISO Abbreviation: Clin. Diagn. Lab. Immunol. Publication Date: 2000 Jul |
Date Detail:
|
Created Date: 2000-09-12 Completed Date: 2000-09-12 Revised Date: 2013-04-17 |
Medline Journal Info:
|
Nlm Unique ID: 9421292 Medline TA: Clin Diagn Lab Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 635-40 Citation Subset: IM |
Affiliation:
|
Livingston Research Institute, University of Southern California School of Medicine, Los Angeles, California 90033, USA. krodgers@hsc.usc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin II
/
pharmacology*,
therapeutic use Animals Bacterial Infections / immunology, prevention & control Granulocyte Colony-Stimulating Factor / pharmacology, therapeutic use Macrophage Activation / drug effects, immunology Macrophages, Peritoneal / drug effects*, immunology* Mice Mice, Inbred C57BL Mycoses / immunology, prevention & control Peritonitis / immunology*, prevention & control Phagocytosis / drug effects*, immunology Rats Rats, Sprague-Dawley Recombinant Proteins |
| Chemical | |
Reg. No./Substance:
|
0/Recombinant Proteins; 11128-99-7/Angiotensin II; 121181-53-1/Filgrastim; 143011-72-7/Granulocyte Colony-Stimulating Factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Parasporin, a human leukemic cell-recognizing parasporal protein of Bacillus thuringiensis.
Next Document: Comparison of a monoclonal antibody-blocking enzyme-linked immunoassay and a strip immunoblot assay ...