Document Detail

Angiotensin II increases host resistance to peritonitis.
MedLine Citation:
PMID:  10882664     Owner:  NLM     Status:  MEDLINE    
Studies by other laboratories have shown that angiotensin II (AII) can affect the function of cells which comprise the immune system. In the present study, the effect of AII on the function of peritoneal macrophages and peripheral blood monocytes was assessed. In vitro exposure (4 h prior to assay) of peritoneal macrophages from mice and rats to AII increased the percentage of cells that phagocytosed opsonized yeast and the number of yeast per macrophage. Furthermore, AII increased the respiratory burst capacity of peritoneal macrophages from mice and rats and peripheral blood mononuclear cells from humans. Because of these observations, the effect of AII on host resistance to bacterial infection was assessed. Intraperitoneal administration of AII was shown to increase host resistance (reduced abscess formation) in an animal model of bacterial peritonitis. Studies were then conducted to assess whether parenteral administration of AII, a clinically relevant route, could affect peritoneal host resistance in a manner similar to that observed after peritoneal administration. These studies showed that subcutaneous administration of AII throughout the postinfection interval increased the level of host resistance to bacterial peritonitis. Furthermore, in a study which compared AII and Neupogen, an agent approved for use for the reduction of febrile neutropenia after myeloablative therapy, daily subcutaneous administration of AII reduced abscess size and incidence, whereas Neupogen did not have any therapeutic benefit in this model. These data suggest that AII may be of therapeutic benefit as an immunomodulatory agent.
K Rodgers; S Xiong; T Espinoza; N Roda; S Maldonado; G S diZerega
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and diagnostic laboratory immunology     Volume:  7     ISSN:  1071-412X     ISO Abbreviation:  Clin. Diagn. Lab. Immunol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-12     Completed Date:  2000-09-12     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  9421292     Medline TA:  Clin Diagn Lab Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  635-40     Citation Subset:  IM    
Livingston Research Institute, University of Southern California School of Medicine, Los Angeles, California 90033, USA.
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MeSH Terms
Angiotensin II / pharmacology*,  therapeutic use
Bacterial Infections / immunology,  prevention & control
Granulocyte Colony-Stimulating Factor / pharmacology,  therapeutic use
Macrophage Activation / drug effects,  immunology
Macrophages, Peritoneal / drug effects*,  immunology*
Mice, Inbred C57BL
Mycoses / immunology,  prevention & control
Peritonitis / immunology*,  prevention & control
Phagocytosis / drug effects*,  immunology
Rats, Sprague-Dawley
Recombinant Proteins
Reg. No./Substance:
0/Recombinant Proteins; 11128-99-7/Angiotensin II; 121181-53-1/Filgrastim; 143011-72-7/Granulocyte Colony-Stimulating Factor

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