Document Detail

Angiotensin II does not inhibit vagally-induced bradycardia or gastric contractions in the anaesthetized ferret.
MedLine Citation:
PMID:  6478113     Owner:  NLM     Status:  MEDLINE    
The effects of angiotensin II (AII) and the analogue Sar1-Leu8-angiotensin II on the changes in heart rate and gastric pressure induced by vagal stimulation were investigated in the urethane-anaesthetized ferret. AII at high doses (500 ng kg-1 i.v.) increased blood pressure and decreased gastric pressure whereas Sar1-Leu8-AII at the same dose had a much smaller effect on blood pressure and no effect on gastric pressure. Intravenous injections or infusions of AII or its analogue did not alter the effect of vagal stimulation on heart rate or gastric motility. Our results do not provide support for the proposal that AII modulates parasympathetic activity at peripheral sites (Potter, 1982a, b).
P L Andrews; M B Dutia; P J Harris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  82     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-11-14     Completed Date:  1984-11-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  833-7     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / analogs & derivatives,  pharmacology*
Blood Pressure / drug effects
Carnivora / physiology*
Electric Stimulation
Ferrets / physiology*
Gastrointestinal Motility / drug effects*
Heart Rate / drug effects*
Vagus Nerve / physiology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 53814-27-0/sarleucin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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