Document Detail


Angiotensin II does not inhibit vagally-induced bradycardia or gastric contractions in the anaesthetized ferret.
MedLine Citation:
PMID:  6478113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of angiotensin II (AII) and the analogue Sar1-Leu8-angiotensin II on the changes in heart rate and gastric pressure induced by vagal stimulation were investigated in the urethane-anaesthetized ferret. AII at high doses (500 ng kg-1 i.v.) increased blood pressure and decreased gastric pressure whereas Sar1-Leu8-AII at the same dose had a much smaller effect on blood pressure and no effect on gastric pressure. Intravenous injections or infusions of AII or its analogue did not alter the effect of vagal stimulation on heart rate or gastric motility. Our results do not provide support for the proposal that AII modulates parasympathetic activity at peripheral sites (Potter, 1982a, b).
Authors:
P L Andrews; M B Dutia; P J Harris
Related Documents :
10450063 - Effects of eprosartan on glomerular injury in rats with reduced renal mass.
2976233 - Transmural distribution of biochemical markers of total protein and collagen synthesis,...
21067343 - Effect of doxazosin gits on blood pressure in hypertensive and normotensive patients: a...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  82     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-11-14     Completed Date:  1984-11-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  833-7     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anesthesia
Angiotensin II / analogs & derivatives,  pharmacology*
Animals
Blood Pressure / drug effects
Carnivora / physiology*
Electric Stimulation
Electrocardiography
Ferrets / physiology*
Gastrointestinal Motility / drug effects*
Heart Rate / drug effects*
Male
Vagus Nerve / physiology*
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II; 53814-27-0/sarleucin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of methysergide and 5-hydroxytryptamine on carotid blood flow distribution in pigs: further ...
Next Document:  Hydrodynamic properties of muscarinic acetylcholine receptors solubilized from rat forebrain.