| Angiotensin II does not alter ACTH responses to hypoglycemia in conscious dogs. | |
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MedLine Citation:
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PMID: 3030143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These experiments were designed to test for an interaction between angiotensin II (ANG II) and stress in the control of plasma adrenocorticotropin hormone (ACTH), corticosteroids, and aldosterone. The stimulus to ACTH used in this study was insulin-induced hypoglycemia, a stimulus that does not increase plasma ANG II concentrations. Five trained dogs with exteriorized carotid arteries were studied. Each dog was infused with ANG II intravenously (10 ng X kg-1 X min-1) or into the carotid artery (1 ng X kg-1 X min-1) or with saline (iv) for 80 min. Twenty minutes after the start of the infusion, insulin (0.10 U/kg iv) was injected. Intravenous infusion of ANG II increased mean arterial pressure (MAP) and plasma aldosterone concentrations but did not increase ACTH or corticosteroid responses to hypoglycemia. Intracarotid infusion of ANG II did not increase MAP and also failed to increase ACTH and corticosteroid responses to hypoglycemia. Since ANG II infusions did not increase basal corticosteroids, the failure of ANG II to stimulate ACTH is not a result of steroid negative feedback. Thus it appears that increased plasma ANG II concentrations do not increase ACTH responses to hypoglycemic stress. |
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Authors:
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M Keller-Wood; B Kimura; M I Phillips |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 252 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-04-16 Completed Date: 1987-04-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R526-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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blood Adrenocorticotropic Hormone / blood* Aldosterone / blood Angiotensin II / administration & dosage, pharmacology* Animals Blood Pressure Carotid Arteries Dogs Female Hypoglycemia / blood* Injections, Intra-Arterial Injections, Intravenous Male Stress, Physiological / blood |
| Grant Support | |
ID/Acronym/Agency:
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AM-07436/AM/NIADDK NIH HHS; HL-27334/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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