Document Detail

Angiotensin II control of the renal microcirculation: effect of blockade by saralasin.
MedLine Citation:
PMID:  3747343     Owner:  NLM     Status:  MEDLINE    
The hydronephrotic rat kidney with intact circulation and innervation was split and spread out as a thin sheet in a tissue bath. The microvasculature was observed in vivo via television microscopy. We quantitated the effects of increasing concentrations (10(-9) to 10(-5) M) of saralasin (angiotensin II antagonist) applied locally in the tissue bath on microvascular diameters and on relative glomerular blood flow (measured using fluorescent labeled RBCs). Saralasin produced an increase in preglomerular diameters which was largest (37 +/- 11%) in the interlobular artery (there was no dilation in the afferent arteriole near the glomerulus), an increase in postglomerular diameters which was largest (17 +/- 4%) in the efferent arteriole near the glomerulus, and an increase in blood flow (19 +/- 4%). If these types of findings would hold for the normal kidney, it would suggest a role for angiotensin II in the control of total renal blood flow, in the regional distribution of flow, and in the control of filtration fraction. We also made control micropressure measurements using the servo-nulling approach. Pressures measured were: afferent arteriole, 65 +/- 5 mm Hg; intraglomerulus, 50 +/- 5 mm Hg; and efferent arteriole, 19 +/- 3 mm Hg. These data indicate that there is major vascular resistance near the glomerulus, especially in the efferent arteriole.
M Steinhausen; H Kücherer; N Parekh; S Weis; D L Wiegman; K R Wilhelm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  30     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-10-01     Completed Date:  1986-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  56-61     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / biosynthesis,  pharmacology*
Arterioles / drug effects
Blood Pressure / drug effects
Dose-Response Relationship, Drug
Hydronephrosis / physiopathology
Kidney Glomerulus / drug effects
Microcirculation / drug effects
Rats, Inbred Strains
Renal Circulation / drug effects*
Saralasin / pharmacology*
Vasodilation / drug effects
Reg. No./Substance:
11128-99-7/Angiotensin II; 34273-10-4/Saralasin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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