| Angiotensin II contributes to the increased baseline leg vascular resistance in spinal cord-injured individuals. | |
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MedLine Citation:
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PMID: 20577118 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Spinal cord-injured (SCI) individuals demonstrate an increased baseline leg vascular resistance (LVR). In addition, despite the lack of sympathetic control, an increase in LVR is observed during orthostatic challenges. On the basis of the vasoconstrictive characteristics of angiotensin II, we examined the hypothesis that angiotensin II contributes to the LVR at baseline and during head-up tilt (HUT) in SCI individuals. METHODS: Supine baseline leg and forearm blood flow were measured using venous occlusion plethysmography and leg blood flow during 30° HUT using duplex ultrasound. Measurements were performed before and 4 h after an angiotensin II antagonist (irbesartan, 150 mg) administered in eight SCI individuals and eight age-matched and sex-matched able-bodied controls. Vascular resistance was calculated as the arterial-venous pressure gradient divided by blood flow. RESULTS: Angiotensin II blockade significantly decreased baseline LVR in SCI individuals (P = 0.02) but not in controls, whereas no changes in forearm vascular resistance were found in both groups. Angiotensin II blockade did not alter the increase in LVR during HUT in SCI individuals nor in controls. CONCLUSION: Our results indicate that angiotensin II contributes to the increased baseline LVR in SCI individuals. As angiotensin II does not contribute to forearm vascular resistance, the contribution to LVR may relate to the extreme inactivity of the legs in SCI individuals. Angiotensin II does not contribute to the increase in LVR during HUT in SCI individuals nor in controls. |
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Authors:
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Jan T Groothuis; Dick H J Thijssen; Gerard A Rongen; Jaap Deinum; A H Jan Danser; Alexander C H Geurts; Paul Smits; Maria T E Hopman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 2094-101 Citation Subset: IM |
Affiliation:
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aDepartment of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin II / physiology* Angiotensin II Type 1 Receptor Blockers / pharmacology Biphenyl Compounds / pharmacology Blood Pressure / drug effects Case-Control Studies Humans Leg / blood supply* Male Middle Aged Spinal Cord Injuries / physiopathology* Supine Position / physiology Tetrazoles / pharmacology Vascular Resistance / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Biphenyl Compounds; 0/Tetrazoles; 11128-99-7/Angiotensin II; 138402-11-6/irbesartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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