| Angiotensin II and cell cycle regulation. | |
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MedLine Citation:
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PMID: 14967829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II has emerged as an important growth factor for vascular, cardiac, and renal cells. Depending on the specific cell type and presence of other growth factors, angiotensin II induces proliferation (replication of DNA with subsequent successful division of cells), hypertrophy (increase in cell size, cell protein, and mRNA content without DNA replication), apoptosis (programmed cell death), or differentiation. Such angiotensin II-mediated modulation of growth process may underlie various pathophysiological processes such as atherosclerosis, vascular and cardiac remodeling, and progression of chronic renal disease. Clearly, angiotensin II-induced proliferation requires complete cell progression through the various steps of the cell cycle. In contrast, cells undergoing angiotensin II-mediated hypertrophy are arrested in the G1-phase. Upregulation of cell cycle-dependent kinase inhibitors (eg, p27Kip1) plays an important role in this process. Although accumulating evidence suggests that apoptosis is cell cycle-dependent, only few data are currently available concerning the interaction of angiotensin II with the cell cycle machinery in apoptosis. We review the various angiotensin II-mediated growth processes and their relationship to events governing cell cycle regulation. |
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Authors:
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Gunter Wolf; Ulrich O Wenzel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2004-02-16 |
Journal Detail:
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Title: Hypertension Volume: 43 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-26 Completed Date: 2004-08-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 693-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, University Hospital, Germany. Wolf@UKE.uni-hamburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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physiology* Animals Apoptosis / physiology Blood Vessels / cytology, growth & development, metabolism Cardiovascular Diseases / metabolism, pathology Cell Cycle / physiology* Cell Cycle Proteins / physiology Cell Differentiation / physiology Cell Division / physiology Cell Size Endothelins / physiology G1 Phase Heart / growth & development, physiology Humans Hypertrophy Kidney / cytology, growth & development, metabolism Kidney Diseases / metabolism, pathology Myocardium / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Endothelins; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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