| Angiotensin II: a candidate for an aldosterone-independent mediator of potassium preservation during volume depletion. | |
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MedLine Citation:
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PMID: 21278776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two different stimulators of aldosterone secretion, high-potassium diet and low-sodium diet, have disparate effects on potassium secretion in the distal nephron. The mechanism by which the kidney preserves potassium in the face of a high-aldosterone, volume-depleted state has engendered much thought. Yue et al. now propose that angiotensin II inhibits the renal outer medullary potassium channel (ROMK1) through stimulation of the protein tyrosine kinase c-Src, perhaps acting as a signal to differentiate volume depletion from a high-potassium diet. |
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Authors:
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Robert S Hoover |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Kidney international Volume: 79 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-05-06 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 377-9 Citation Subset: IM |
Affiliation:
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Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA. robert.hoover@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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metabolism Angiotensin II / metabolism* Animals Diet, Sodium-Restricted Humans Hypovolemia / metabolism* Kidney / metabolism* Models, Biological Potassium / metabolism* Potassium Channels, Inwardly Rectifying Potassium, Dietary / administration & dosage Protein-Tyrosine Kinases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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K08 DK070668/DK/NIDDK NIH HHS; R01 DK085097/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Potassium Channels, Inwardly Rectifying; 0/Potassium, Dietary; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 7440-09-7/Potassium; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/CSK tyrosine-protein kinase |
| Comments/Corrections | |
Comment On:
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Kidney Int. 2011 Feb;79(4):423-31
[PMID:
20927043
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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