Document Detail

Angiotensin II blockade in congestive heart failure.
MedLine Citation:
PMID:  686905     Owner:  NLM     Status:  MEDLINE    
Five of 11 normotensive patients with congestive heart failure responded to an infusion of the specific angiotensin II antagonist, saralasin, by reducing systemic vascular resistance from 2274 +/- 418 to 1690 +/- 351 dynes/sec/cm-5 (mean +/- standard error). This decrease was accompanied by a reduction in left ventricular filling pressure from 19.4 +/- 5.9 to 11.6 +/- 4.0 mm Hg, an increase in cardiac index from 2.2 +/- 0.4 to 2.7 +/- 0.4 l/min/m2 and a decrease in mean arterial pressure from 95 +/- 9.8 to 86 /+- 8.6 mm Hg. In the other 6 patients with congestive heart failure and in 4 controls, saralasin produced either no change or slight increases in systemic vascular resistance. Plasma renin activity did not differentiate responders from non-respnders. Specific inhibition of angiotensin may provide a means for reducing inappropriately high peripheral resistance in some patients with congestive heart failure.
G A Turini; H R Brunner; R K Ferguson; J L Rivier; H Gavras
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  233     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-10-27     Completed Date:  1978-10-27     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  166-76     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / analogs & derivatives*,  antagonists & inhibitors*
Cardiac Output / drug effects
Heart Catheterization
Heart Failure / physiopathology*
Hemodynamics / drug effects
Middle Aged
Saralasin / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
11128-99-7/Angiotensin II; 34273-10-4/Saralasin

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