| Angiotensin II blockade in congestive heart failure. | |
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MedLine Citation:
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PMID: 686905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five of 11 normotensive patients with congestive heart failure responded to an infusion of the specific angiotensin II antagonist, saralasin, by reducing systemic vascular resistance from 2274 +/- 418 to 1690 +/- 351 dynes/sec/cm-5 (mean +/- standard error). This decrease was accompanied by a reduction in left ventricular filling pressure from 19.4 +/- 5.9 to 11.6 +/- 4.0 mm Hg, an increase in cardiac index from 2.2 +/- 0.4 to 2.7 +/- 0.4 l/min/m2 and a decrease in mean arterial pressure from 95 +/- 9.8 to 86 /+- 8.6 mm Hg. In the other 6 patients with congestive heart failure and in 4 controls, saralasin produced either no change or slight increases in systemic vascular resistance. Plasma renin activity did not differentiate responders from non-respnders. Specific inhibition of angiotensin may provide a means for reducing inappropriately high peripheral resistance in some patients with congestive heart failure. |
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Authors:
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G A Turini; H R Brunner; R K Ferguson; J L Rivier; H Gavras |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 233 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-10-27 Completed Date: 1978-10-27 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 166-76 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiotensin II / analogs & derivatives*, antagonists & inhibitors* Cardiac Output / drug effects Female Heart Catheterization Heart Failure / physiopathology* Hemodynamics / drug effects Humans Male Middle Aged Saralasin / pharmacology* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 34273-10-4/Saralasin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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