| Angiotensin II antagonist prevents electrical remodeling in atrial fibrillation. | |
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MedLine Citation:
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PMID: 10840013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The blockade of angiotensin II (Ang II) formation has protective effects on cardiovascular tissue; however, the role of Ang II in atrial electrical remodeling is unknown. The purpose of this study was to investigate the effects of candesartan and captopril on atrial electrical remodeling. METHODS AND RESULTS: In 24 dogs, the atrial effective refractory period (AERP) was measured before, during, and after rapid atrial pacing. Rapid atrial pacing at 800 bpm was maintained for 180 minutes. The infusion of saline (n=8), candesartan (n=5), captopril (n=6), or Ang II (n=5) was initiated 30 minutes before rapid pacing and continued throughout the study. In the saline group, AERP was significantly shortened during rapid atrial pacing (from 149+/-11 to 132+/-16 ms, P<0.01). There was no significant difference in AERP shortening between the saline group and the Ang II group. However, in the candesartan and captopril groups, shortening of the AERP after rapid pacing was completely inhibited (from 142+/-9 to 147+/-12 ms with candesartan, from 153+/-15 to 153+/-14 ms with captopril, P=NS). Although rate adaptation of the AERP was lost in the saline group, this phenomenon was preserved in the candesartan and captopril groups. CONCLUSIONS: The inhibition of endogenous Ang II prevented AERP shortening during rapid atrial pacing. These results indicate for the first time that Ang II may be involved in the mechanism of atrial electrical remodeling and that the blockade of Ang II may lead to the better therapeutic management of human atrial fibrillation. |
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Authors:
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H Nakashima; K Kumagai; H Urata; N Gondo; M Ideishi; K Arakawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 101 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-06-21 Completed Date: 2000-06-21 Revised Date: 2003-12-05 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2612-7 Citation Subset: AIM; IM |
Affiliation:
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Second Department of Internal Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan. kxk@fukuoka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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antagonists & inhibitors*,
pharmacology Animals Antihypertensive Agents / pharmacology* Atrial Fibrillation / drug therapy*, physiopathology* Atrial Function / drug effects, physiology Benzimidazoles / pharmacology* Captopril / pharmacology Dogs Female Heart Conduction System / drug effects, physiopathology* Male Myocardium / chemistry Pacemaker, Artificial Receptor, Angiotensin, Type 1 Receptor, Angiotensin, Type 2 Receptors, Angiotensin / physiology Sinoatrial Node / physiology Tetrazoles / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Benzimidazoles; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Angiotensin, Type 2; 0/Receptors, Angiotensin; 0/Tetrazoles; 11128-99-7/Angiotensin II; 139481-59-7/candesartan; 62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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