| Angiotensin II antagonism improves the lipoprotein profile in patients with nephrotic syndrome. | |
MedLine Citation:
|
PMID: 18800457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To study the effects of the angiotensin II receptor antagonist losartan on the lipid profile of patients with nephrotic range proteinuria. DESIGN: A single-blind, longitudinal study. Patients were followed during four periods each lasting 1 month, in which they received in sequence once-daily placebo, 50 mg losartan, 100 mg losartan and placebo, respectively. Measurements were performed at the end of each study period. PATIENTS: Eleven patients with biopsy-proven renal disease, diastolic blood pressure > or = 90 mmHg, creatinine clearance > or = 50 ml/min, stable proteinuria > or = 2.5 g/day, without familial hyperlipidemia or use of hypolipidemic agents. RESULTS: At the end of the 100 mg losartan period, median arterial blood pressure had fallen from 114.5 +/- 2.3 mmHg at baseline to 96 +/- 2.8 mmHg (P < 0.001). Urinary protein excretion decreased from 6.2 +/- 1.3 g/day to 4.2 +/- 1.3 g/day (P < 0.001), whereas serum albumin and total protein did not change. Total cholesterol fell significantly from 6.67 +/- 0.46 mmol/l to 6.08 +/- 0.42 mmol/l (P = 0.04). This decrease in cholesterol was mainly due to a decrease in very-low-density and low-density lipoprotein cholesterol, though high-density lipoprotein cholesterol also tended to fall. Apolipoprotein B decreased by 13.0 +/- 3.6% (P = 0.05), whereas the apolipoprotein A1 concentration remained unchanged, thus resulting in a significant increase in the apolipoprotein A1/B ratio (12.5 +/- 3.5%, P = 0.05). Lipoprotein(a) concentration fell from 287 +/- 57 mg/l to 218 +/- 35 mg/l (P = 0.07). Interestingly, those patients that had the highest baseline lipoprotein(a) values showed the most outspoken change in lipoprotein(a) levels during treatment. In the placebo recovery period all parameters returned towards baseline values. CONCLUSIONS: In addition to lowering blood pressure and proteinuria, the angiotensin II antagonist losartan improves the lipoprotein profile in patients with nephrotic range proteinuria. |
Authors:
|
D de Zeeuw; R T Gansevoort; R P Dullaart; P E de Jong |
Related Documents
:
|
8336837 - Prevalence of silent st segment depression during long-term ambulatory electrocardiogra... 1391177 - Effects of atherosclerosis on mean and daily variation of arterial pressure in consciou... 22789797 - Effect of a combined nutraceutical containing orthosiphon stamineus effect on blood pre... 15043687 - Blood pressure response to melatonin in type 1 diabetes. 24729217 - Advances in probes and methods for clinical epr oximetry. 2676347 - Inspiratory work of breathing on flow-by and demand-flow continuous positive airway pre... |
Publication Detail:
|
Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 13 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1995 Jul |
Date Detail:
|
Created Date: 2008-09-19 Completed Date: 2008-10-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: England |
Other Details:
|
Languages: eng Pagination: S53-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine, State University Hospital, Groningen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Angiotensin II / antagonists & inhibitors* Angiotensin II Type 1 Receptor Blockers / pharmacology, therapeutic use* Apolipoprotein A-I / blood Apolipoproteins B / blood Blood Pressure / drug effects Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Cholesterol, VLDL / blood Female Humans Lipoproteins / blood* Longitudinal Studies Losartan / pharmacology, therapeutic use* Male Middle Aged Nephrotic Syndrome / blood*, drug therapy* Proteinuria / blood, drug therapy Single-Blind Method Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin II Type 1 Receptor Blockers; 0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipoproteins; 0/Triglycerides; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The pharmacokinetics of losartan in renal insufficiency.
Next Document: The acute and chronic effects of losartan in heart failure.