Document Detail

Angiotensin II activates NADPH oxidase in isolated rat hearts subjected to ischaemia-reperfusion.
MedLine Citation:
PMID:  12591107     Owner:  NLM     Status:  MEDLINE    
The role of angiotensin II in myocardial ischaemia-reperfusion is not clearly defined. In this respect, the involvement of NADPH oxidase remains to be determined. The aim of this study was 1) to evaluate the cardiac effects of angiotensin AT(1) receptor stimulation in non-ischaemic conditions of perfusion or during ischaemia-reperfusion, and 2) to measure the concomitant activation of NADPH oxidase in isolated rat hearts perfused with angiotensin II and/or Losartan. In non-ischaemic hearts, angiotensin II induced rapid and prolonged vasoconstrictive and negative inotropic effects. Ischaemia-reperfusion increased the mRNA expression of AT(1) and AT(2) receptors. During reperfusion, angiotensin II reduced the incidence of arrhythmias and the lactate dehydrogenase released, and increased NADPH oxidase mRNA expression and enzyme activity. Losartan co-administration totally antagonised the effects of angiotensin II. Our study demonstrates that ischaemia-reperfusion induces adaptative cardiac modifications, which allow exogenously added angiotensin II to stimulate myocardial NADPH oxidase through angiotensin AT(1) receptor activation.
Alexandra Oudot; Catherine Vergely; Aline Ecarnot-Laubriet; Luc Rochette
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  462     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-19     Completed Date:  2003-07-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  145-54     Citation Subset:  IM    
Laboratoire de Physiopathologie et Pharmacologie Cardio-vasculaires Expérimentales, Faculties of Medicine and Pharmacy, 7, Boulevard Jeanne d'Arc, BP 87900, 21079 Dijon, France.
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MeSH Terms
Angiotensin II / pharmacology*
Arrhythmias, Cardiac / physiopathology,  prevention & control
Coronary Circulation / drug effects
Enzyme Activation / drug effects
Heart / drug effects*,  physiology,  physiopathology
L-Lactate Dehydrogenase / drug effects,  metabolism
Losartan / pharmacology
Membrane Glycoproteins / genetics
Membrane Transport Proteins*
Myocardial Ischemia / complications*
Myocardial Reperfusion Injury / etiology,  physiopathology*,  prevention & control
Myocardium / enzymology*,  metabolism
NADPH Dehydrogenase / genetics
NADPH Oxidase / genetics,  metabolism*
Phosphoproteins / genetics
RNA, Messenger / drug effects,  genetics,  metabolism
Rats, Wistar
Vasoconstrictor Agents / pharmacology
Ventricular Function, Left / drug effects,  physiology
Reg. No./Substance:
0/CYBB protein, human; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Phosphoproteins; 0/RNA, Messenger; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; EC Dehydrogenase; EC protein, human; EC Oxidase; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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