Document Detail

Angiotensin. II. Important role in the maintenance of arterial blood pressure.
MedLine Citation:
PMID:  4347166     Owner:  NLM     Status:  MEDLINE    
An angiotensin II antagonist, [1-sarcosine, 8-alanine]-angiotensin II, was given intravenously to anesthetized dogs with thoracic caval constriction and ascites to investigate the role of angiotensin II in the control of arterial pressure. The antagonist produced a striking fall in arterial pressure and in aldosterone secretion and an accompanying increase in plasma renin activity. In a control experiment, normal anesthetized dogs were given the angiotensin analog, but it failed to reduce arterial pressure or to influence plasma renin activity. In conscious dogs with caval constriction, the antagonist produced essentially the same drop in arterial pressure as observed in anesthetized animals. These results suggest an important role for angiotensin II in the maintenance of arterial pressure by its action on specific receptor sites in arteriolar smooth muscle and in the adrenal cortex.
J A Johnson; J O Davis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  179     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1973 Mar 
Date Detail:
Created Date:  1973-04-16     Completed Date:  1973-04-16     Revised Date:  2011-12-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  906-7     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / drug effects
Alanine / pharmacology
Aldosterone / secretion
Angiotensin II / antagonists & inhibitors,  pharmacology,  physiology*
Blood Pressure*
Femoral Artery
Hydrocortisone / secretion
Regional Blood Flow / drug effects
Renin / blood
Sarcosine / pharmacology
Vena Cava, Inferior
Reg. No./Substance:
107-97-1/Sarcosine; 11128-99-7/Angiotensin II; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 56-41-7/Alanine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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