| Angiotensin. II. Important role in the maintenance of arterial blood pressure. | |
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MedLine Citation:
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PMID: 4347166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An angiotensin II antagonist, [1-sarcosine, 8-alanine]-angiotensin II, was given intravenously to anesthetized dogs with thoracic caval constriction and ascites to investigate the role of angiotensin II in the control of arterial pressure. The antagonist produced a striking fall in arterial pressure and in aldosterone secretion and an accompanying increase in plasma renin activity. In a control experiment, normal anesthetized dogs were given the angiotensin analog, but it failed to reduce arterial pressure or to influence plasma renin activity. In conscious dogs with caval constriction, the antagonist produced essentially the same drop in arterial pressure as observed in anesthetized animals. These results suggest an important role for angiotensin II in the maintenance of arterial pressure by its action on specific receptor sites in arteriolar smooth muscle and in the adrenal cortex. |
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Authors:
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J A Johnson; J O Davis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 179 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1973 Mar |
Date Detail:
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Created Date: 1973-04-16 Completed Date: 1973-04-16 Revised Date: 2011-12-27 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 906-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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drug effects Alanine / pharmacology Aldosterone / secretion Angiotensin II / antagonists & inhibitors, pharmacology, physiology* Animals Ascites Blood Pressure* Dogs Female Femoral Artery Hydrocortisone / secretion Ligation Regional Blood Flow / drug effects Renin / blood Sarcosine / pharmacology Vena Cava, Inferior |
| Chemical | |
Reg. No./Substance:
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107-97-1/Sarcosine; 11128-99-7/Angiotensin II; 50-23-7/Hydrocortisone; 52-39-1/Aldosterone; 56-41-7/Alanine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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