| Angiotensin II and Cardiac Fibrosis. | |
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MedLine Citation:
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PMID: 21232296 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The renin-angiotensin system has been linked to the pathogenesis of cardiac fibrosis through the use of experimental animal models and by clinical studies. This review emphasizes recent findings implicating the direct action of angiotensin II on cardiac cell types, particularly the cardiac fibroblast, as a causative factor in the development of cardiac fibrosis. The possible influence of other factors acting in concert with angiotensin II either to increase or to attenuate the fibrotic process is also discussed. Nitric oxide is considered as an example of a paracrine agent that can antagonize either the hemodynamic or cellular effects of angiotensin II during both physiological and pathological processes. (Trends Cardiovasc Med 1996;6:193-198). |
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Authors:
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P Brecher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 6 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 2011-01-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 193-8 Citation Subset: - |
Copyright Information:
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Copyright © 1996 Elsevier Science Inc. All rights reserved. |
Affiliation:
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Department of Biochemistry and The Cardiovascular Institute, Boston University School of Medicine,Boston, MA 02118,USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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