| Angiotensin AT2 receptors regulate cerebral blood flow in rats. | |
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MedLine Citation:
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PMID: 1520859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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LARGE cerebral arteries have been reported to contain angiotensin receptors that are exclusively of the AT2 subtype. We measured the effect of the AT2 receptor selective ligand PD 123319 on cerebral blood flow (CBF) in rats, using laser-doppler flowmetry. PD 123319 (1-10 mg kg-1) dose-dependently inhibited the increase in CBF, when the blood pressure was increased by a norepinephrine infusion. However, PD 123319 did not alter baseline CBF at normal blood pressures. Therefore PD 123319 appears to interfere with the autoregulatory mechanisms of CBF. The participation of AT2 receptors in the regulation of CBF confirms a physiological role for this receptor subtype, and may give clues for future treatment of various cerebrovascular disorders. |
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Authors:
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C Strömberg; L Näveri; J M Saavedra |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroreport Volume: 3 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-10-15 Completed Date: 1992-10-15 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 703-4 Citation Subset: IM |
Affiliation:
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Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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metabolism,
pharmacology* Animals Blood Pressure / drug effects* Cerebrovascular Circulation / drug effects, physiology* Dose-Response Relationship, Drug Hypertension / chemically induced, physiopathology, prevention & control Imidazoles / pharmacology Male Norepinephrine / pharmacology* Pyridines / pharmacology Rats Rats, Inbred Strains Receptors, Angiotensin / antagonists & inhibitors, drug effects, physiology* Sodium Chloride |
| Chemical | |
Reg. No./Substance:
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0/Imidazoles; 0/Pyridines; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 130663-39-7/PD 123319; 51-41-2/Norepinephrine; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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