| Angiotensin AT1 receptor subtypes in the rabbit pulmonary artery. A ligand binding study. | |
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MedLine Citation:
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PMID: 9826909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present ligand binding study showed that the rabbit pulmonary artery contained two subtypes of losartan-sensitive angiotensin receptor. The two receptor subtypes are differentially distributed. The high affinity receptor subtype is located predominantly in the cardia end of the artery while the low affinity receptor subtype is found mainly in the pulmonary portion of the artery. The Kd for the high and low affinity receptors for sar1, Ile8-angiotensin II was found to be 0.25 +/- 0.005 and 0.88 +/- 0.02 nM, respectively; and for angiotensin II to be 0.43 +/- 0.001 and 0.96 +/- 0.02 nM, respectively. In the presence of 1 mM GppNHp, the high affinity receptor subtype was converted to the low affinity subtype, indicating that it is G-protein coupled. 1 mM GppNHp had no effect on the low affinity receptor subtype. The present data support the findings of an earlier functional study which also showed the existence and similar differential distribution of two losartan-sensitive angiotensin receptors in the rabbit pulmonary artery. However, the significance of these findings in regard to the regulation of pulmonary circulation in normal and pathological conditions remains to be investigated. |
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Authors:
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M K Sim; S L Lim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Receptors & channels Volume: 5 ISSN: 1060-6823 ISO Abbreviation: Recept. Channels Publication Date: 1998 |
Date Detail:
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Created Date: 1999-02-02 Completed Date: 1999-02-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9315376 Medline TA: Receptors Channels Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 323-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, National University of Singapore, Singapore. phcsimmk@nus.sg |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin I
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physiology* Animals GTP-Binding Proteins / physiology Ligands Pulmonary Artery / physiology* Rabbits Radioligand Assay Receptors, Angiotensin / agonists, physiology* Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Receptors, Angiotensin; 9041-90-1/Angiotensin I; EC 3.6.1.-/GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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