| Angiotensin-(1-7) prevents diabetes-induced attenuation in PPAR-gamma and catalase activities. | |
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MedLine Citation:
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PMID: 20447391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms by which angiotensin-(1-7) [Ang-(1-7)] exerts its beneficial effects on end-organ damage associated with diabetes and hypertension are not well understood. The purpose of this study was A) to compare the effects of apocynin with Ang-(1-7) on renal vascular dysfunction and NADPH oxidase activity in a combined model of diabetes and hypertension and B) to further determine whether chronic treatment with Ang-(1-7) can modulate renal catalase, and peroxisome proliferator activated receptor- gamma (PPAR-gamma) levels in streptozotocin-induced diabetes in both normotensive Wistar Kyoto rats (WKY) and in spontaneously hypertensive rats (SHR). Apocynin or Ang-(1-7) treatment for one month starting at the onset of diabetes similarly attenuated elevation of renal NADPH oxidase activity in the diabetic SHR kidney and reduced the degree of proteinuria and hyperglycemia, but had little or modest effect on reducing mean arterial pressure. Both drugs also attenuated the diabetes-induced increase in renal vascular responsiveness to endothelin-1. Induction of diabetes in WKY and SHR animals resulted in significantly reduced renal catalase activity and in PPAR-gamma mRNA and protein levels. Treatment with Ang-(1-7) significantly prevented diabetes-induced reduction in catalase activity and the reduction in PPAR-gamma mRNA and protein levels in both animal models. Taken together, these data suggest that activation of Ang-(1-7)-mediated signaling could be an effective way to prevent the elevation of NADPH oxidase activity and inhibition of PPAR-gamma and catalase activities in diabetes and/or hypertension. |
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Authors:
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Gursev S Dhaunsi; Mariam H M Yousif; Saghir Akhtar; Mark C Chappell; Debra I Diz; Ibrahim F Benter |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-04 |
Journal Detail:
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Title: European journal of pharmacology Volume: 638 ISSN: 1879-0712 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-09-27 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 108-14 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetophenones
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administration & dosage,
pharmacology Angiotensin I / administration & dosage, pharmacology* Animals Antihypertensive Agents / administration & dosage, pharmacology* Antioxidants / administration & dosage, pharmacology Blood Glucose / drug effects Blood Pressure / drug effects Catalase / metabolism* Diabetes Mellitus, Experimental / complications, drug therapy, metabolism* Endothelin-1 / antagonists & inhibitors Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) / metabolism Hyperglycemia / drug therapy Hypertension / complications, drug therapy, metabolism, physiopathology Kidney / drug effects, metabolism, physiopathology Male NADPH Oxidase / metabolism PPAR gamma / metabolism* Peptide Fragments / administration & dosage, pharmacology* Proteinuria / drug therapy Rats Rats, Inbred SHR Rats, Inbred WKY Renal Artery / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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HL-51952/HL/NHLBI NIH HHS; HL-56973/HL/NHLBI NIH HHS; P01 HL051952-150007/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetophenones; 0/Antihypertensive Agents; 0/Antioxidants; 0/Blood Glucose; 0/Endothelin-1; 0/PPAR gamma; 0/Peptide Fragments; 0/angiotensin I (1-7); 498-02-2/acetovanillone; 9041-90-1/Angiotensin I; EC 1.11.1.6/Catalase; EC 1.2.1.12/Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); EC 1.6.3.1/NADPH Oxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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