Document Detail


Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension.
MedLine Citation:
PMID:  7536715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
New studies suggest that vasodilator systems may play an important role in restraining the rise in peripheral vascular resistance associated with the evolution of arterial hypertension. We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega-nitro-L-arginine (3 mg.kg-1.d-1) or the nitric oxide precursor L-arginine (0.3 mg.kg-1.d-1) during the evolution of two-kidney, one clip hypertension. Inhibition of nitric oxide production elicited a form of hypertension more severe than that produced in placebo-fed two-kidney, one clip dogs. The higher levels of blood pressure were accompanied by lower levels of plasma renin activity and lower angiotensin II concentrations. During the chronic phase of renovascular hypertension, the fall in blood pressure produced by acute systemic injections of lisinopril or losartan was significantly reduced in dogs given the nitric oxide inhibitor. In contrast, chronic administration of L-arginine had no effect on the magnitude of hypertension or on the increases in renin activity and hyperangiotensinemia associated with the evolution of renal hypertension. Likewise, the fall in blood pressure produced by pharmacological blockade of angiotensin II was not different from that recorded in untreated renal hypertensive dogs. The vasodilator component of the blood pressure response due to intravenous injections of angiotensin-(1-7) (1 to 100 nmol/kg) was augmented in both untreated and L-arginine-treated two-kidney, one clip hypertensive dogs, but was significantly attenuated in hypertensive dogs fed the nitric oxide synthase inhibitor.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H Nakamoto; C M Ferrario; S B Fuller; D L Robaczewski; E Winicov; R H Dean
Related Documents :
20651825 - Intracavernosal administration of sodium nitrite as an erectile pharmacotherapy.
10609385 - Molecular mechanisms of response to low oxygen tension in the vascular wall.
1951535 - Enhanced endothelium-derived relaxing factor activity in pregnant, spontaneously hypert...
9458915 - Systemic inhibition of nitric oxide and prostaglandins in volume-induced natriuresis an...
20723725 - Single double-lumen venous-venous pump-driven extracorporeal lung membrane support.
8498655 - Early administration of amrinone does not impair regional metabolism of o2 or lactate a...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  25     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2012-07-03    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  796-802     Citation Subset:  IM    
Affiliation:
Hypertension Center, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1032, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Oxidoreductases / antagonists & inhibitors
Angiotensin II / antagonists & inhibitors,  pharmacology*
Angiotensins / blood
Animals
Arginine / analogs & derivatives,  pharmacology
Biphenyl Compounds / pharmacology
Dogs
Hemodynamics / drug effects
Hypertension, Renovascular / physiopathology*
Imidazoles / pharmacology
Lisinopril / pharmacology
Losartan
Male
Nitric Oxide / physiology*
Nitric Oxide Synthase
Nitroarginine
Peptide Fragments / pharmacology*
Peptidyl-Dipeptidase A / metabolism
Tetrazoles / pharmacology
Grant Support
ID/Acronym/Agency:
1PO1-HL-51952/HL/NHLBI NIH HHS; R01-HL-50066/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiotensins; 0/Biphenyl Compounds; 0/Imidazoles; 0/Peptide Fragments; 0/Tetrazoles; 0/angiotensin I (1-7); 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 2149-70-4/Nitroarginine; 74-79-3/Arginine; 83915-83-7/Lisinopril; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells.
Next Document:  Effect of angiotensin II blockade on the fibroproliferative response to phenylephrine in the rat hea...