Document Detail

Angiotensin-(1-7) and nitric oxide interaction in renovascular hypertension.
MedLine Citation:
PMID:  7536715     Owner:  NLM     Status:  MEDLINE    
New studies suggest that vasodilator systems may play an important role in restraining the rise in peripheral vascular resistance associated with the evolution of arterial hypertension. We characterized in conscious dogs the hemodynamic and hormonal effects of 4 weeks of feeding either the nitric oxide synthase inhibitor N omega-nitro-L-arginine (3 or the nitric oxide precursor L-arginine (0.3 during the evolution of two-kidney, one clip hypertension. Inhibition of nitric oxide production elicited a form of hypertension more severe than that produced in placebo-fed two-kidney, one clip dogs. The higher levels of blood pressure were accompanied by lower levels of plasma renin activity and lower angiotensin II concentrations. During the chronic phase of renovascular hypertension, the fall in blood pressure produced by acute systemic injections of lisinopril or losartan was significantly reduced in dogs given the nitric oxide inhibitor. In contrast, chronic administration of L-arginine had no effect on the magnitude of hypertension or on the increases in renin activity and hyperangiotensinemia associated with the evolution of renal hypertension. Likewise, the fall in blood pressure produced by pharmacological blockade of angiotensin II was not different from that recorded in untreated renal hypertensive dogs. The vasodilator component of the blood pressure response due to intravenous injections of angiotensin-(1-7) (1 to 100 nmol/kg) was augmented in both untreated and L-arginine-treated two-kidney, one clip hypertensive dogs, but was significantly attenuated in hypertensive dogs fed the nitric oxide synthase inhibitor.(ABSTRACT TRUNCATED AT 250 WORDS)
H Nakamoto; C M Ferrario; S B Fuller; D L Robaczewski; E Winicov; R H Dean
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  25     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2012-07-03    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  796-802     Citation Subset:  IM    
Hypertension Center, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157-1032, USA.
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MeSH Terms
Amino Acid Oxidoreductases / antagonists & inhibitors
Angiotensin II / antagonists & inhibitors,  pharmacology*
Angiotensins / blood
Arginine / analogs & derivatives,  pharmacology
Biphenyl Compounds / pharmacology
Hemodynamics / drug effects
Hypertension, Renovascular / physiopathology*
Imidazoles / pharmacology
Lisinopril / pharmacology
Nitric Oxide / physiology*
Nitric Oxide Synthase
Peptide Fragments / pharmacology*
Peptidyl-Dipeptidase A / metabolism
Tetrazoles / pharmacology
Grant Support
Reg. No./Substance:
0/Angiotensins; 0/Biphenyl Compounds; 0/Imidazoles; 0/Peptide Fragments; 0/Tetrazoles; 0/angiotensin I (1-7); 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II; 114798-26-4/Losartan; 2149-70-4/Nitroarginine; 74-79-3/Arginine; 83915-83-7/Lisinopril; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases; EC A

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