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Angioscopy study from a large patient population comparing sirolimus-eluting stent with biodegradable versus durable polymer.
MedLine Citation:
PMID:  21953920     Owner:  NLM     Status:  Publisher    
AIMS: This study aimed to compare the neointimal coverage (NIC), subclinical thrombus, color of plaque underneath the stent at 9-month after implantation of sirolimus-eluting stent (SES) either with durable or with biodegradable polymer (BDPM). METHODS: A total of 175 patients were assigned as Cypher (n=81, 97 stents with durable polymer) and Excel (n=94, 112 stents with BDPM) stent at 9-month after indexed procedure. NIC was classified from Grade 0-3. Color of plaque was divided into white, light-yellow, yellow and dark yellow. Thtombus was diagnosed as white or red material with cotton-like or ragged appearance. Incomplete NIC (Grade 0/1) circled by a blush was termed by "inflaming". RESULTS: There were signicficant differences in unstable angina (90.5% vs. 52.4%, p=0.015), previous myocardial infarction (33.3% vs. 4.0%, p=0.045) and left ventricular eject fraction (55.2±7.8% vs. 62.6±6.3%, p=0.021) between the Excel and Cypher groups. The minimal- and maximal-NIC grades in the Cypher group were 0.67±0.58 and 2.29±0.46, respectively, compared to 1.45±0.67 (p<0.001) and 2.64±0.49 (p=0.023) in the Excel group. The percentage of yellow plaque, thrombus, "inflaming" and NIC grade of 0 in the Excel and Cypher groups, respectively, were as follow: 8.0% vs. 26.8% (p=0.031), 9.8% vs. 32.9% (p=0.024), 8.0% vs. 38.1% (p=0.017) and 38.1% vs. 0% (p<0.001). Of the stents with "inflaming", 63.6% had thrombus compared to 20.1% of the non-erosion stents (p<0.001). Overlapping segments had the lowest NIC grades and more "inflaming" demonstrating a significant difference between Cypher vs. Excel stents. NIC grade was positively correlated with thrombus. CONCLUSIONS: SES with BDPM has improved NIC resulting in less yellow plaque, thrombus and "inflaming". Overlapping segments had the lowest NIC grade and more "inflaming". © 2011 Wiley-Liss, Inc.
Shao-Liang Chen; Tian Xu; Jun-Jie Zhang; Fei Ye; Zuo-Ying Hu; Nai-Liang Tian; Yao-Jun Zhang; Jun-Ichi Kotani; Jun-Xia Zhang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-27
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Division of Cardiology, Nanjing First Hospital, Nanjing Medical University, 210006 Nanjing, China; Division of Cardiology, Nanjing Heart Center, 21006 Nanjing, China.
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