Document Detail


Angioscopic study of silent plaque disruption in nonischemic related coronary artery in patients with stable ischemic heart disease.
MedLine Citation:
PMID:  21173512     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Plaque disruption, which may be associated with some coronary risk factors, plays a key role in the development of acute coronary syndromes and progression of atherosclerosis. However, the clinical profile of asymptomatic plaque disruption in stable ischemic heart disease has not been well evaluated. The aim of the present study was to investigate the frequency and determinants of silent plaque disruption (SPD) in patients with stable ischemic heart disease using coronary angioscopy. Forty-one patients with stable angina or old myocardial infarction (OMI) without any complaints within 3 months were included in the present study. Angioscopy was successfully performed through 49 nonischemic related coronary arteries. The presence of SPD and coronary risk factors were recorded. Silent plaque disruption was found in 12 patients with stable ischemic heart disease (12/41, 29.3%), and the frequency of SPD in nonischemic related coronary arteries was 26.5% (13/49). A significantly higher frequency of SPD was noted in yellow plaques than in white plaques (35.3% versus 6.7%, P = 0.043). Overall, the independent clinical risk factors of SPD in nonischemic related coronary arteries were diabetes mellitus (P = 0.018; OR, 18.8209; 95% CI, 1.6525 to 214.3523) and hypertension (P = 0.0313; OR, 6.6485; 95% CI, 1.1850 to 37.3019). These results suggest silent plaque disruption was commonly observed in nonischemic related coronary arteries in patients with stable ischemic heart disease and its determinants were diabetes mellitus and hypertension.
Authors:
Zuoyan Wang; Shigenobu Inami; Sonoko Kirinoki; Hideo Yamamoto; Gen Takagi; Satoshi Aoki; Koji Kato; Hitoshi Takano; Kuniya Asai; Masahiro Yasutake; Masamichi Takano; Masatoshi Yamamoto; Takayoshi Ohba; Kyoichi Mizuno
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  51     ISSN:  1349-3299     ISO Abbreviation:  Int Heart J     Publication Date:  2010  
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  383-7     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Nippon Medical School.
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