Document Detail

Angiosarcomas associated with bone infarcts.
MedLine Citation:
PMID:  9840390     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A bone infarct may occasionally dedifferentiate to osteogenic sarcoma, fibrosarcoma or malignant fibrous histiocytoma. However, the association of an angiosarcoma with a bone infarct is extremely rare. Such an association is presented in three patients. Their clinical course is compared with that of patients with bone infarcts associated with other sarcomas. DESIGN AND PATIENTS: The three patients were men with a mean age of 43 years. Cases 1 and 3 presented with a pathological fracture at the site of the angiosarcoma. Plain radiography was done in the three patients, computed tomography (CT) was performed in cases 1 and 3 and magnetic resonance imaging (MRI) in case 3. The femur was the site of the three tumors: midshaft in cases 1 and 3 and distal shaft in case 2. On the basis of the radiographic findings, and clinical examination, an open biopsy was performed for the three men, which confirmed the diagnosis of a high-grade angiosarcoma associated with a bone infarct. RESULTS: Case 1 was treated with high-above knee amputation and is still alive after 18 months from the time of operation. Segmental resection of the distal femur with adjuvant chemotherapy and local irradiation was the treatment for case 2, who is still alive with no tumor recurrence on metastatic disease 3 years from the operation. Intramedullary rodding was done for case 3 who died 6 months later. CONCLUSION: The association of an angiosarcoma with a bone infarct has been established in only five cases. Although the number of such associations is small, it seems that such an association may be prognostically more or less the same as in those cases in which a bone infarct is associated with either osteosarcoma, fibrosarcoma or malignant fibrous histiocytoma, where the survival rate is unfavorable. A cause-and-effect relationship may exist between a bone infarct and subsequent development of a bone sarcoma.
I F Abdelwahab; M J Klein; G Hermann; D Springfield
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Skeletal radiology     Volume:  27     ISSN:  0364-2348     ISO Abbreviation:  Skeletal Radiol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-20     Completed Date:  1999-01-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7701953     Medline TA:  Skeletal Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
Department of Radiology, Mount Sinai Medical Center, New York, NY 10029-6574, USA.
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MeSH Terms
Fatal Outcome
Femoral Fractures / etiology
Femoral Neoplasms / complications,  diagnosis*,  pathology,  surgery
Femur / blood supply*,  pathology,  radiography,  surgery
Fractures, Spontaneous / etiology
Hemangiosarcoma / complications,  diagnosis*,  pathology,  surgery
Infarction / diagnosis*,  etiology,  pathology,  surgery
Magnetic Resonance Imaging
Middle Aged
Tomography, X-Ray Computed

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