Document Detail

Angiopoietins, abdominal aortic aneurysm and atherosclerosis.
MedLine Citation:
PMID:  20832800     Owner:  NLM     Status:  MEDLINE    
Abdominal aortic aneurysm (AAA) and atherosclerosis are common causes of mortality and morbidity in an aging population. Angiogenesis is believed to contribute to the development and progression of these diseases. Angiopoietins (angpts) are known to be important regulators of angiogenesis. Angpts can also influence inflammation and have been shown to possess both pro-atherosclerotic and atheroprotective effects. This review explores the potential roles that the angpts play in the development and progression of AAA and atherosclerosis.
Alexandra F Trollope; Jonathan Golledge
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-19
Journal Detail:
Title:  Atherosclerosis     Volume:  214     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-05-23     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  237-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
The Vascular Biology Unit, School of Medicine and Dentistry, James Cook University, Douglas Campus, Townsville, QLD 4811, Australia.
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MeSH Terms
Angiopoietins / metabolism*
Aortic Aneurysm, Abdominal / metabolism*,  pathology,  physiopathology
Atherosclerosis / metabolism*,  pathology,  physiopathology
Disease Progression
Inflammation Mediators / metabolism
Neovascularization, Pathologic / metabolism*,  physiopathology
Signal Transduction
Grant Support
R01 HL080010-05/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Angiopoietins; 0/Inflammation Mediators

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