Document Detail

Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins.
MedLine Citation:
PMID:  16806062     Owner:  NLM     Status:  MEDLINE    
Angiopoietin-related growth factor (AGF) is a newly identified member of angiopoietin-related proteins (ARPs)/angiopoietin-like proteins (Angptls). AGF has been considered as a novel growth factor in accelerating cutaneous wound healing, as it is capable of stimulating keratinocytes proliferation as well as angiogenesis. But in our paper, we demonstrate that AGF stimulates keratinocytes proliferation only at high protein concentration, however, it can potently promote adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells. Furthermore, we confirm that the adhesion and migration cellular events are mediated by RGD-binding integrins, most possibly the alpha(v)-containing integrins, by in vitro inhibition assays using synthetic competitive peptides. Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism.
Yueqing Zhang; Xiaobo Hu; Ruiyang Tian; Wangui Wei; Wei Hu; Xia Chen; Wei Han; Huayou Chen; Yi Gong
Publication Detail:
Type:  Journal Article     Date:  2006-06-19
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  347     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-11     Completed Date:  2006-09-13     Revised Date:  2010-04-12    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  100-8     Citation Subset:  IM    
Shanghai Institute for Biological Sciences, Graduate school of Chinese Academy of Sciences, Shanghai, PR China.
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MeSH Terms
Biological Factors / administration & dosage*
Cell Adhesion / drug effects,  physiology
Cell Aggregation / drug effects,  physiology
Cell Line
Cell Movement / drug effects,  physiology
Dose-Response Relationship, Drug
Endothelial Cells / cytology,  drug effects,  physiology*
Fibroblasts / cytology,  drug effects,  physiology*
Integrin alpha Chains / metabolism*
Integrins / metabolism
Keratinocytes / cytology,  drug effects,  physiology*
Oligopeptides / metabolism*
Signal Transduction / drug effects,  physiology
Reg. No./Substance:
0/ANGPTL6 protein, human; 0/Angiopoietins; 0/Biological Factors; 0/Integrin alpha Chains; 0/Integrins; 0/Oligopeptides; 99896-85-2/arginyl-glycyl-aspartic acid

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