| Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships. | |
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MedLine Citation:
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PMID: 22462789 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Angiopoietin-like protein 4 (ANGPTL4) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and is secreted into the bloodstream in glycosylated, oligomerized, native and cleaved isoforms to modulate physiological events such as angiogenesis, cell differentiation and the crosstalk between liver, brain, adipose and muscle tissue in lipid and glucose metabolism. In addition, the expression and isoform appearance of ANGPTL4 are modified by the intestinal microbiota. With an eye on an effective strategy to improve health using ANGPTL4, we will focus on: health issues associated with ANGPTL4 expression, including obesity, Type 2 diabetes, cardiovascular diseases and cancer; several modulators of ANGPTL4 of chemical, microbiological, food and host origin; and the correlation of the specific ANGPTL4 isoforms with these modulators and their health effects. |
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Authors:
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Charlotte Grootaert; Tom Van de Wiele; Willy Verstraete; Marc Bracke; Barbara Vanhoecke |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of proteomics Volume: 9 ISSN: 1744-8387 ISO Abbreviation: Expert Rev Proteomics Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101223548 Medline TA: Expert Rev Proteomics Country: England |
Other Details:
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Languages: eng Pagination: 181-99 Citation Subset: IM |
Affiliation:
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Laboratory of Microbial Ecology & Technology (LabMET), Ghent University, B-9000 Ghent, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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