| Angiopoietin balance in septic shock patients treated by direct hemoperfusion with polymyxin b-immobilized fiber. | |
| | |
MedLine Citation:
|
PMID: 19954476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Capillary permeability is a tightly regulated feature of microcirculation in all organ beds; however, in sepsis this feature is fundamentally altered. We previously reported elevated levels of vascular endothelial growth factor and its receptor (fms-like tyrosine kinase-1) in patients with septic shock, then investigated two kinds of angiopoietins in those patients. An enzyme-linked immunoassay was used to measure serum angiopoietin-1 and -2 levels in 12 patients with septic shock who were treated by direct hemoperfusion with a polymyxin B-immobilized fiber column (DHP-PMX). The angiopoietin-1 level was lower in patients with septic shock (7.01 +/- 10.08 ng/mL) than in controls (28.24 +/- 11.61 ng/mL, P < 0.001), but the angiopoietin-2 level was higher in septic shock patients (40.83 +/- 30.13 ng/mL vs. 2.47 +/- 1.78 ng/mL, P < 0.001). Between seven survivors and five non-survivors there was no significant difference in angiopoietin-1 levels before DHP-PMX therapy. During DHP-PMX therapy, however, the angiopoietin-2 level was significantly decreased in survivors (31.52 +/- 26.15 ng/mL vs. 17.32 +/- 22.46 ng/mL, P = 0.035). Moreover, at the end of the therapy, the angiopoietin-1 level was significantly lower in non-survivors (1.14 +/- 1.30 ng/mL vs. 10.43 +/- 13.56 ng/mL, P = 0.042), but the angiopoietin-2 level in non-survivors was significantly higher (70.79 +/- 40.47 ng/mL vs. 17.32 +/- 22.46 ng/mL, P = 0.019). The angiopoietin-2 level may be associated with vascular permeability in septic patients, and angiopoietins may be suitable markers of disease severity and mortality. |
| | |
Authors:
|
Itaru Ebihara; Kouichi Hirayama; Kei Nagai; Tomoko Kakita; Yasunori Miyamoto; Miho Nagai; Yujiro Ogawa; Shogo Fujita; Homare Shimohata; Hirayasu Kai; Joichi Usui; Kunihiro Yamagata; Masaki Kobayashi |
Related Documents
:
|
21600906 - Hormonal and behavioral responses to stress in lactating and non-lactating female commo... 20584716 - Relationship between serum infliximab levels and acute uveitis attacks in patients with... 21615236 - Influence of sex hormones in women on breast elasticity measured by shear wave sonoelas... 15749556 - Diclofenac phonophoresis in human volunteers. 1715746 - Identification of serum proteins, thyroglobulin and antithyroid antibodies in the fluid... 20098446 - Pituitary gland: predictors of acromegaly-associated mortality. |
Publication Detail:
|
Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 13 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-03 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
|
Languages: eng Pagination: 520-7 Citation Subset: IM |
Affiliation:
|
Department of Nephrology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan. itaruebi@yahoo.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Angiopoietin-1 / blood* Angiopoietin-2 / blood* Biological Markers / blood Capillary Permeability Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Hemoperfusion / methods* Humans Male Middle Aged Polymyxin B / chemistry Severity of Illness Index Shock, Septic / mortality, physiopathology, therapy* Survivors |
| Chemical | |
Reg. No./Substance:
|
0/ANGPT1 protein, human; 0/Angiopoietin-1; 0/Angiopoietin-2; 0/Biological Markers; 1404-26-8/Polymyxin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hemoperfusion with an immobilized polymyxin B fiber column decreases macrophage and monocyte activit...
Next Document: Hemoperfusion with a polymyxin B fiber column decreases clotting activity.