Document Detail


Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74).
MedLine Citation:
PMID:  19913849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to look at the association of angiopoietin-2 (Ang-2) in Asian Indian subjects with different grades of glucose intolerance and in those with hypertension and metabolic syndrome (MS). Three groups were recruited from the Chennai Urban Rural Epidemiology Study, a population-based study in southern India, as follows: group 1, normal glucose tolerance(n = 45); group 2, impaired glucose tolerance (IGT) (n = 45); and group 3, type 2 diabetes mellitus (T2DM) (n = 40). Angiopoietin-2 was estimated by enzyme-linked immunosorbent assay. Hypertension was diagnosed based on medical history, drug treatment of hypertension, and/or if the subjects had systolic blood pressure at least 130 mm Hg and/or diastolic blood pressure at least 85 mm Hg. Metabolic syndrome was defined using modified National Cholesterol Education Program-Adult Treatment Panel III guidelines. Subjects with T2DM had higher age-adjusted Ang-2 values (3741 +/- 1429 pg/mL) compared with subjects with IGT (1907 +/- 855 pg/mL) and normal glucose tolerance (1462 +/- 856 pg/mL) (P for trend < .001). Regression analysis showed that there was a linear increase in mean Ang-2 values with increasing severity of glucose intolerance, even after adjusting for age, sex, and body mass index. Angiopoietin-2 levels were also elevated in subjects with hypertension (P = .004) and in subjects with MS even in the absence of fasting hyperglycemia (P = .011). There was also a linear increase in the mean values of Ang-2 with increase in number of components of MS (P for trend < .001). This study demonstrates that increased levels of Ang-2 are seen in Asian Indian subjects with IGT, T2DM, and hypertension and in subjects with MS even in the absence of fasting hyperglycemia.
Authors:
Sathish Anuradha; Viswanathan Mohan; Kuppan Gokulakrishnan; Madhulika Dixit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-14
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  59     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  774-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Madras Diabetes Research Foundation & Dr Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control, Gopalapuram, Chennai 600086, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Angiopoietin-2 / metabolism*
Anthropometry
Diabetes Mellitus, Type 2 / epidemiology,  metabolism
Female
Glucose Intolerance / epidemiology,  metabolism*
Glucose Tolerance Test
Humans
Hypercholesterolemia / blood,  epidemiology
Hypertension / epidemiology,  metabolism*
India / epidemiology
Male
Metabolic Syndrome X / epidemiology,  metabolism*
Middle Aged
Regression Analysis
Risk Factors
Rural Population
Urban Population
Chemical
Reg. No./Substance:
0/Angiopoietin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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