Document Detail


Angiopoietin-1 and -2 expression in recurrent squamous cell carcinoma of the oral cavity.
MedLine Citation:
PMID:  18161864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: Our objective was to evaluate the clinical significance of angiopoietin-1 (Ang-1) and Ang-2 expression in recurrent but operable squamous cell carcinoma of the oral cavity (OCSCC). PATIENTS AND METHODS: Formalin-fixed, paraffin-embedded tissues from 40 patients who underwent surgical intervention for local or local-regional recurrent OCSCC between 1995 and 2005 were immunohistochemically analyzed for Ang-1 and Ang-2 expression. RESULTS: The recurrent TNM staging classified 5 patients as stage I, 4 as stage II, 2 as stage III, and 29 as stage IV. The actuarial 3-year disease-free survival rate was 43.1% with a mean follow-up of 18.4 months (ranged 1-70 months). High expression of Ang-1 was significantly correlated with positive nodal stage (P = 0.041). Patients with more advanced recurrent stage of the tumors (P = 0.0036) and high expression of Ang-2 (P = 0.045) showed lower actuarial 3-year disease-free survival. However, Cox's regression analysis revealed that only recurrent tumor (rT) stage was an independent prognostic factor for survival (P = 0.019, 95% CI = 1.473-82.017, relative risk = 10.992). CONCLUSIONS: Recurrent OCSCC with high Ang-1 or Ang-2 expression in the tumor bed exhibits aggressive tumor behavior. However, the salvage outcome depends on the rT stage.
Authors:
Chih-Yen Chien; Chih-Ying Su; Hui-Ching Chuang; Fu-Min Fang; Hsuan-Ying Huang; Ching-Mei Chen; Chang-Han Chen; Chao-Cheng Huang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of surgical oncology     Volume:  97     ISSN:  0022-4790     ISO Abbreviation:  J Surg Oncol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-14     Completed Date:  2008-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-7     Citation Subset:  IM    
Copyright Information:
2007 Wiley-Liss, Inc
Affiliation:
Department of Otolaryngology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angiopoietin-1 / metabolism*
Angiopoietin-2 / metabolism*
Carcinoma, Squamous Cell / metabolism*,  mortality,  pathology
Cohort Studies
Female
Humans
Male
Middle Aged
Mouth Neoplasms / metabolism*,  mortality,  pathology
Neoplasm Recurrence, Local / metabolism*,  mortality,  pathology
Neoplasm Staging
Pilot Projects
Predictive Value of Tests
Survival Analysis
Chemical
Reg. No./Substance:
0/ANGPT1 protein, human; 0/Angiopoietin-1; 0/Angiopoietin-2

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